Review: Ion mobility spectroscopy a new method of analysis, its application and reproducibility problems

Manoj Charde, P. B. Ghanawat, R. D. Chakole

Abstract


Ion Mobility Spectrometry (IMS) is a mass-selective technique in which the sample is vaporised, ionised, and with given initial velocity moved along a drift region towards a collector electrode. The drift times (milliseconds, ms) needed by the ions to reach the collector are proportional to their masses: the higher the mass, the longer the drift times. During our evaluation of ion mobility spectrometry in the screening it was found that reproducibility problem may occurred which is solve easily by using some methods, described in this review. Ion mobility spectroscopy is widely use for the drug analysis, hair analysis and other applications.


Keywords


Ion Mobility Spectroscopy (IMS), Reproducibility,

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Copyright (c) 2014 International Journal of Advances in Pharmaceutics