A prospective study of evaluation of methods to decrease the morbidity in oral submucous fibrosis

Dr. Kamal Devgan, Dr. Priyank Mistry, Dr. Tapan Nagpal


Aim: To evaluate the effect of antioxidants, intralesional steroids and laser in decreasing morbidity in patients of oral submucous fibrosis

Introduction: Oral submucous fibrosis (OSMF) is a chronic disorder characterized by progressive fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oropharynx, and rarely the upper third of the esophagus, resulting in intolerance to spicy foods, burning sensation in the mouth, limitation of mouth opening and tongue mobility, xerostomia, dysphagia and hoarseness. OSMF has been reported to occur commonly in conjunction with premalignant diseases such as leukoplakia and lichen planus and therefore aprecursor to oral cavity cancer in many cases.

Materials and Methods: This prospective study included 60 patients with OSMF attending the Ear Nose & Throat Clinic of Dhiraj Hospital, Piparia. Patients of OSMF were evaluated as per Performa and for proper treatment planning were broadly classified into 4 groups based on classification suggested by Sinha et al.

Conclusion: Lycopene, an antioxidant has significant response in early cases of OSMF in decreasing the burning pain in oral cavity in OSMF. Inj. triamcinolone and Inj. hyaluronidase, given submucosally havesignificant response in early cases of OSMF to improve cheek flexibility.CO2 laser have significant results in achieving satisfactory mouth opening in OSMF but notcheek flexibility.


Oral submucous fibrosis, lycopene, laser, triamcinolone

Full Text:



Mukherji AL, Biswas SK. Oral submucous fibrosis- A search for etiology. Indian J Otolaryngol. 1972; 24:11-5.

Schwartz J. Effects of the medicinal mushroom Agaricusblazei Murill on immunity, infection and cancer. AtrophiaIdiopathica Mucosae Oris. London1952.

Joshi SG. Fibrosis of the palate and pillars. Indian J Otolaryngol 1952; 4:1-4.

Cox SC and Walker DM. Oral submucous fibrosis. A review. Aust Dent J 1996; 41(5):294-299.

Fareedi Mukram Ali, Prasant MC, Ashok Patil et al. Oral Submucous Fibrosis: Medical Management. GJMEDPH. Jan-Feb 2012; 1(1): 11-17.

Pinheiro ABB, Frame JW. An audit of CO2 laser surgery in the mouth. Braz Dent J. 1994; 5(1):15-25.

Rajendran R. Oral submucous fibrosis-etiology, pathogenesis and future research. Bull World Health Organ. 1994; 72:985-96.

Canniff JP, Harvey W, Harris M. Oral submucous fibrosis: Its pathogenesis and management. Br Dent J 1986; 160:429-34.

Trivedy CR, Warnakulsuriya KAAS et al. Raised tissue copper levels in oral submucous fibrosis. J Oral Pathol Med 2000; 29:241-248.

Gandhi G, Kaur, Sharma S. Chewing Pan Masala and/or Betel Quid- Fashionable Attributes and/or Cancer Menaces? J. Hum. Ecol. 2005; 17(3):161-166.

Trivedy C, WarnakulsuriyaKaas, Hazarey VK, Tavassoli M, Sommer P, Johnson NW. The up-regulation of lysyl oxidase in oral submucous fibrosis and squamous cell carcinoma. J Oral Pathol Med 1999; 28:246-251.

Gupta PC, Sinor PN, Bhonsle RB, Pawar VS, Mehta HC. Oral submucous fibrosis in India: a new epidemic? Natl Med J India 1998; 11 (3):113-6.

Pindborg JJ. Is submucous fibrosis a precancerous condition in the oral cavity? Int. Dent. J 1972; 22:474-480.

Borle RM, Borle SR. Management of oral submucosal fibrosis, a conservative approach. Journal of Oral and Maxillofacial Surgery. 1991; 49:788-91.

Desa JV. Submucous fibrosis of the palate and cheek. Ann Otol Rhin and Laryng 1957; 66:1043-59.

Pindborg JJ, Sirsat, SM. Oral Submucous Fibrosis. Oral Surg, Oral Med, Oral Pathol 1966; 22(6):764-779.

Chaturvedi VN, Sharma AK, Marathe NG. Intraoral injection of hydrocortisone and hyaluronidase in oral submucous fibrosis. Indian Prac 1990; 575-580.

Lai DR, Chen HR, Lin LM, Huang YL, Tsai CC. Clinical evaluation of different treatment methods for oral submucous fibrosis. A 10- year experience with 150 cases. J Oral Pathol Med 1995;24:402-406.

Paymaster JC. Cancer of the buccal mucosa; a clinical study of 650 cases in Indian patients. Cancer. 1956 May-Jun;9(3):431–435.

Borle RM, Borle SR. Management of oral submucous fibrosis: A conservative approach. J Oral Maxillofacsurg 1991; 49:788-791.

DOI: http://dx.doi.org/10.7439/ijasr.v1i1.1660

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


  • There are currently no refbacks.

Copyright (c) 2015 International Journal of Advances in Scientific Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.