A correlative study of peptic ulcer and thrombocytopenia in Remo land of Ogun State, Nigeria.

John Cletus Ihongbe, Ayodele Ilesanmi, Isaac Oluwole Adediji, Ufuoma Laju Otomewo, Adewumi Olasebikan

Abstract


ABSTRACT

Introduction: Helicobacter pylori infection is one of the commonest bacterial infections in human world-wide. H.pylori is a significant cause of a number of intra-digestive and extra-digestive disorders with increased prevalence in the developing countries.

Objectives: This study investigated the relationship between platelet count and peptic ulcer and also compared the results of the test subjects with the controls.

Methodology: Sixty subjects (age: 27.5±3.2) were enrolled for the study which included forty newly diagnosed peptic ulcer patients from the Medical Outpatient Clinic of a tertiary health institution in Ogun State, Nigeria and twenty age-matched, apparently healthy individuals from the same geographical location were selected as controls. Platelet count analysis was done with BC-5300 Auto Haematology analyzer and the detection of serum H.pylori antibodies was done using diaspot rapid chromatographic immunoassay method. Data obtained were statistically analysed using ANOVA, Post-Hoc and Pearson’s correlation. P<0.05 was considered significant.

Results: The platelet count was significantly low in H.pylori infected peptic ulcer subjects when compared with both H.pylori negative peptic ulcer subjects and controls (p<0.05). There was no significant difference in the platelet count of H.pylori negative peptic ulcer subjects when compared with controls. There was a significant negative correlation between platelet count and H.pylori seropositivity (p<0.05) and also there was a significant positive correlation between platelet count and H.pylori seronegativity (p<0.05).

Conclusion: The study concluded that, not all cases of peptic ulcer are associated with thrombocytopenia however, thrombocytopenia in peptic ulcer subjects, is solely associated with H.pylori infection.


Keywords


Key words: Helicobacter pylori, Peptic ulcer, Thrombocytopenia, Immunoassay

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DOI: http://dx.doi.org/10.7439/ijbar.v6i7.2173

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