Visual evoked potential changes in diabetes mellitus

Kiran Narayan Avachar, Nikhil Pandurang Sonawane, Mundewadi Shafique Ahmed, Shrinivas Janardan Kashalikar

Abstract


 Background: Diabetes Mellitus (DM) a metabolic disorder is the most common cause of neuropathy. Electrophysiological studies are commonly employed to detect the neuropathy. The present study was undertaken to find out the utility of visual evoked potential (VEP) as an early indicator of central neuropathy in diabetic patients.

Materials & methods: The present study was carried out in 60 healthy subjects and 60 diagnosed DM patients of age group 20 to 40 years. Visual evoked potential (VEP) tests were recorded in sports physiology laboratory of Medical College on an outpatient basis, using RMS EMG.EP machine. It is to find out whether the VEP latencies are altered in diabetes or not.

 Result: In our study there is statistically significant increase in latencies of P100 waves of both eyes in diabetic patients as compared to control subjects (p < 0.001). The N75-P100 amplitude is decreased in diabetic patients as compared to control subject but it is not statistically significant   (p > 0.05).

Conclusion:  The abnormalities in the VEP response occur in diabetic patients before the development of overt retinopathy. So, VEP measurements can be used for the early diagnosis of central neuropathy to offer an early opportunity for proper management.


Keywords


Diabetes Mellitus (DM), VEP, P100 wave, retinopathy

Full Text:

PDF

References


Puvanendran K, Devathasan G, Wong PK. Visual evoked responses in diabetes.J. Neurol Neurosurg Psychiatry 1983; 46: 643-7.

G B Mukartihal, S. Radhakrishnan et al. Design and development of visual evoked potentials recording system for diagnosis of optic nerve diseases. J. Instrum. Soc. India 2006; 36(4): 227-234.

American Clinical Neurophysiology Society. Guideline 5: guidelines for standard electrode position nomenclature. J Clin Neurophysiol 2006; 23:107–110.

Misra UK, Kalita J. Clinical Neurophysiology. 2nd edition 2006: 309-24.

Varkonyi TT, Peto T, Degi R, Keresztes K, Lengyel C, Janaky M, et al. Impairment of visual evoked potentials. An early central manifestation of diabetic neuropathy. Diabetes Care 2002; 25:1661-2.

Dolu H, Ulas VH, Bolu E, Ozkardes A, Odabasi Z, Ozata M, et al. Evaluation of central neuropathy in type II diabetes mellitus by mutlimodel evoked potentials. Acta Neurol Belg 2003; 103(4): 2006-11.

Azal O, Ozkardes A, Onde ME, Ozata M, Ozisik G, Corakc A, et al. Visual Evoked Potentials in Diabetic Patients. Tr. J. of Medical Sciences 1998; 28:139-42.

Szabela DA, Loba J, Palenga-Pydyn D, Tybark, Ruxer J, Split W. The picture of visual evoked potentials in type 2 diabetes mellitus. Klin Oczna 2005; 107(7):498-501

Li P, Yang Y. Pattern reversal visual evoked potentials analysis in patients with noninsulin dependent diabetes mellitus. Human Yi Ke Da Xve Xve Bao 2001;26(3):283-4.

Atilla H, Tekeli O, Ornek K et al. Pattern electroretinography and visual evoked potentials in optic nerve diseases. J Clin Neurosci. 2006 Jan; 13(1):55-9.

Karlica D, Galetović D et al. Visual evoked potential can be used to detect a prediabetic form of diabetic retinopathy in patients with diabetes mellitus type I. Coll Antropol. 2010 Jun; 34(2): 525-9

McDonald WI. Conduction in the optic nerve. Trans Ophthalmol Soc UK, 1976; 96:352-4.

SK Bhadada, RK Sahay et al. Diabetic Neuropathy: Current Concepts. Indian Academy of Clinical Medicine. October-December 2001; Vol. 2, No. 4:305-318.




DOI: http://dx.doi.org/10.7439/ijbar.v6i7.2270

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Refbacks

  • There are currently no refbacks.




Copyright (c) 2015 International Journal of Biomedical and Advance Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.