Formulation and in vitro evaluation of Metformin HCl mucoadhesive tablets for NIDDM

Huma Kouser, Santosh Kumar Chinnaiyan


The objective of the present work was to develop an oral Mucoadhesive Metformin hydrochloride tablet for the sustained-release. Metformin hydrochloride (HCl), a biguanide, has a relatively short plasma half-life and low absolute bioavailability. The tablets were prepared by the Wet Granulation method, using biodegradable mucoadhesive polymer Xanthan gum and pectin at different concentrations. All the batches were evaluated for thickness, weight variation, hardness, drug content uniformity, in vitro drug release and mucoadhesion strength. Mean dissolution time is used to characterize the drug release rate from a dosage form, and indicates the drug release-retarding efficiency of the polymer. The in vitro studies the formulations containing Pectin showed less retardation than the formulation with Xanthan gum. The Metformin release effectively controlled for 12 h with Xanthan gum, thus, can be successfully employed for formulating mucoadhesive tablets. Fitting the data to the Zero order and Higuchi equation indicated the mechanism of drug release. The study reveals that Xanthan gum highest mucoadhesive strength compared with pectin.


Metformin hydrochloride, Xanthan gum, pectin, mucoadhesive tablets.

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. Takeuchi H, Thongborisute J, Matsui Y, Sugihara H, Yamamoto H, and Kamashima Y, Novel Mucoadhesion tests for polymers and polymercoated particles to design optimal mucoadhesive drug delivery systems. Adv. Drug del. Rev, 2005; 57: 1583-1594.

. Bravo-osuna I, Vauthier C, Farabollini A, Palmieri G F, and Ponchel G, Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutiyl cyanoacrylate) core-shell nanoparticles. Biomaterials, 2007; 28: 2233-2243.

. Andrews G, Laverty T P, and jones D, Mucoadhesive polymeric platforms for controlled drug delivery, Eur. J. Pharm. Biopharm., 2008; 71: 505-51.

. Damodar R, and Movva B, Preparation and In-vitro Evaluation of Metformin HCl Tablets Containing Sustained Release Beads for Increasing Therapeutic Window. J Bioequiv, 2014; 6: 91-95.

. Nicklin P, Keates AC, Page T, Bailey CJ. Transfer of Metformin across monolayers of human intestinal Caco-2 cells and across rat intestine. Int J Pharm, 1996; 128: 155-162.

. Guhan B, Peter T, Douglas SG, Punit HM. In vitro-in vivo correlation (IVIVC) models for Metformin after administration of modified release (MR) oral dosage forms to healthy human volunteers. Drug Dev Ind Pharm, 2001; 90(8): 1176-1185.

. Taggart CM, Ganley JA, Sickmuller A, Walker SE. The evaluation of formulation and processing conditions of melt granulation process. Int J Pharm, 1984; 19: 139-48.

. Royce A, Suryvansh J, Shah U and Vishupad K. Alternative granulation technique: Meltgranulation. Drug Dev Ind Pharm 1996; 22: 917-924.

. Akelesh T, Sapkal S B, Sivakumar R, R.Jothi, and Venkatnarayanan R, Formulation development of Gastro retentive floating tablet of acyclovir using natural gums. Der Pharmacia Lettre, 2011; 3: 254-261.

. Deb Jyotirmoy, Ghosh Amitava, Sen Kumar Kalyan, Prasenjit Paul, and Ananta Choudhury, Formulation and Evaluation of Metformin HCl Floating Tablet using Pectin as a Natural Polymer. Int R J Pharm Sci, 2010; 1: 1-10.

. Grabovac V, Guggi D, and Bernkop-schnurch A, Comparison of the mucoadhesive properties of various polymers. Adv. Drug Del. Rev., 2005; 57: 1713-1723.

. Kumar N, Mahasweta roy, Kumar B, Pooja puri, and Hasan M, Formulation and Evaluation of Sustained Released Metformin HCl Tablet Using Natural Polymers. IJPPR, 2016; 6: 217-237.

. Amish Ashvinkumar Dangi, Ganure Ashoke L, and Jain Divya, Formulation and Evaluation of Colon Targeted Drug delivery System of Levetiracetam using Pectin as Polymeric carrier. J Applied Pharm Sc, 2013; 3: 078-087.

. Callens C, Ceulemans J, Ludwig A, Foreman P, and Remon J P, Rheological study on Mucoadhesivity of some Nasal powder formulations. Eur. J. Pharm. Biopharm, 2003; 55: 323-328.

. Ceulemans J, Vinckier I, and Ludwig A, The use of Xantan gum in an ophthalmic liquid dosage form: rheological characterization of the interaction with mucin. J. Pharm. Sc., 2002; 91: 1117-1127.

. Chowdary C P R, and Rao, Y S, Mucoadhesive microspheres for controlled drug delivery. Biol. Pharm. Bull, 2004; 27: 1717-1724.

. Kwabena Ofori-Kwakye, Kwadwo Amanor Mfoafo, Samuel Lugrie Kipo, Noble Kuntworbe, and Mariam El Boakye-Gyasi, Development and evaluation of natural gum-based extended release matrix tablets of two model drugs of different water solubilities by direct compression. Saudi Pharm J, 2016; 24: 82- 91.

. Mathiowitz E, Chickering D E, and Lehr C M, Bioadhesive drug delivery systems: fundamentals, novel approaches, and development. Drugs and the pharmaceutical sciences. marcel dekke, 1999; 696: 22-37.

. Rana Abu-Huwaij, Rana M, Obaidat, Kamal Sweidan, and Yusuf Al-Hiari, Formulation and In Vitro Evaluation of Xanthan Gum or Carbopol 934-Based Mucoadhesive Patches, Loaded with Nicotine. AAPS Pharm Sci Tech. 2011; 12: 27-34.


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