Study of plasma Leukotriene B4 levels in patients with alcoholic and nonalcoholic fatty liver disease

Haresingh Makwane, Meena Varma, Rajesh Kumar Jha


Background:  In worldwide, alcoholic and nonalcoholic fatty liver disease is a most common global health problem. Liver disease is characterized by inflammation and fibrosis. Leukotrienes B4 are implicated in an inflammation of liver cells. The aim of this study was estimation of LTB4 in pateint with alcoholic and non alcoholic fatty liver disease.

Materials and Methods: In the present research study, we recruited total (n = 435) subjects and divided in alcoholic fatty liver disease (n = 149); nonalcoholic fatty liver disease (n = 137), and healthy control subjects (n = 150). Plasma LTB4 was measurement of ELISA method.

Results: The present study shown that significantly increased levels of plasma LTB4 (p<0.001) in AFLD patients as compared with healthy controls, and also significantly increased (p <0.001) in NFALD patients when they compared with healthy controls.

Conclusion: The identification of mechanism underlying the function of receptor that mediates responses of LTB4, and development of novel therapeutic agents for liver disease.


Nonalcoholic fatty liver disease (NAFLD), Alcoholic fatty liver disease (AFLD), leukotrine B4 (LTB4)

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