Comparative study of fine needle aspiration cytology, trucut biopsy and final histopathological examination in breast lumps

Ajitha M B, Vinod Babu B, Avinash Chandra Singh

Abstract


Background: A lump in the breast results in anxiety for the patient and her family whether benign or malignant. Histological tissue diagnosis is a universally accepted means of definitive diagnosis of a breast lump. FNAC gives a rapid diagnosis and can be carried out in outpatient services with minimal trauma. Hence FNAC is gaining wide acceptance. Trucut biopsy is a safe method for a histological diagnosis, in operable breast cancer cases and a reliable technique to assess hormone receptor status. The trucut needle is a very handy instrument and it is now replacing the incision or excision biopsy.

Aim: To find out the diagnostic accuracy of FNAC and trucut biopsy as compared to the final histopathological report in breast lumps. To compare diagnostic accuracy of FNAC and trucut biopsy in differentiating the benign and malignant lesions of palpable breast lumps.

Methodology: This is a prospective study which included 70 patients having breast lump were subjected to FNAC and Trucut biopsy in Victoria hospital, Bangalore between October1, 2015 to September30, 2016 and were compared to final tissue diagnosis after subsequent admission and treatment. Various factors like age, size, duration, marital status, menstrual status and site were studied during statistical analysis.

Results: There were 70 patients who presented with breast lump during the study period. Out of a total 70 breast lump study, final diagnosis was 36 benign breast lump and 34 malignant breast lumps. Sensitivity of FNAC and TRUCUT biopsy were 86.84% and 97.14% respectively. While TRUCUT was more accurate when compared to FNAC.


Keywords


FNAC, Trucut biopsy, breast lump, breast malignancy

Full Text:

PDF

References


Masood S, frykberg ER, Mclellan GL et al. Prospective evaluation of radiologically directed fine- needle aspiration biopsy of non palpable breast lesions. Cancer 1990; 66:1480-7.

Eman Muhammad et al. validity of fine needle aspiration cytology in diagnosis of breast lumps in upper Egypt, J. Med. Lab. Sci., 2012; 21(1):69-81.

Page DL, Johnson JE, Dupont WD. Probabilistic approach to reporting of fine-needle aspiration cytology of the breast. Cancer Cytopathol 1997; 81:6-9.

Florentine BD, Cobb CJ, Frankel K et al. core needle biopsy: a useful adjunct to fine-needle aspiration in select patients with palpable breast cancer. Cancer Pathol 1997; 81:33-9.

Ballo MS, Sneige N. Can core needle biopsy replace fine needle aspiration cytology in the diagnosis of palpable breast carcinoma? Cancer 1996; 78:773-7.

Homesh N A, Issa M A et al. The diagnostic accuracy of fine needle aspiration cytology versus core needle biopsy for palpable breast lump(s).Saudi Med J 2005; 26(1): 42-46.

Martell G, Pilotti S, Coopmans de Yoldi G et al. Diagnosis efficacy of physical examination, mammography, fine needle aspiration cytology (triple test) in solid breast lumps: an analysis of 1708 consecutive cases. Tumori 1990; 76:476-9.

Mohamed T Musa M I, Randa Z A Khair et al., Diagnosis of Breast Cancer: is there any protocol which is applicable worldwide? Sudan JMS, June 2009;4(2):157-162

Caruso ML, Gabrielli G, Marzullo G, Pirrelli M, Rizzi E, Sorino F. Core Biopsy as Alternative to Fine-Needle Aspiration Biopsy in Diagnosis of Breast Tumors, The Oncologist 1998;3:45-49.

Schwartz’s principles of Surgery: 9th Edition 2010, pg 450.

Patel, J.J., Gartell, P.C., Smallwood, J.A. et al. Fine needle aspiration cytology of breast masses: an evaluation of its accuracy and reasons for diagnostic failure. Ann R Coll Surg Engl. 1987; 69: 156–159.

Pisano, E.D, Fajardo, L.L., Tsimikas, J. et al. Rate of insufficient samples for fine-needle aspiration for nonpalpable breast lesions in a multicenter clinical trial. The Radiologic Diagnostic Oncology Group 5 Study. Cancer 1998; 82(4):679–688.

Masood, Sh. Core needle biopsy versus fine needle aspiration biopsy: are there similar sampling and diagnostic issues?. Clin Lab Med. 2005; 25: 679–688.

Mendelson EB, Tobin CE. Ultrasound-guided interventions: fine needle aspiration and large-core needle biopsy. RSNA categorica course in breast imaging; 1995. 139–49.

Maniero MB, Philpotts LE, Lee CH, et al. Stereotaxic core needle biopsy of breast microcalcifications: correlation of target accuracy and diagnosis with lesion size. Radiology 1996; 198: 665–9.

Vargas H, Masood S. Implementation of a minimal invasive breast biopsy program in countries with limited resources. Breast J 2003; 9(2): 81–5.

Joulaee A, Kalantari M, Kadivar M, Joulaee S, Bahrani N, Mangual M, Hosseini S, Gh. Etemadmoghadam G. Trucut biopsy of breast lesions: The first step toward international standards in developing countries. European Journal of Cancer 2012; 48:648– 654.




DOI: http://dx.doi.org/10.7439/ijbr.v8i3.3829

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 International Journal of Biomedical Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.