Antiulcer Properties of Herbal Drugs: A Review

Dayananda Bhoumik, Birhanetensay Masresha, Arunabha Mallik


Herbal medicines are very important to cure the various ailments of human. Demands of the herbal medicines are increasing in both developed and under developed countries due to growing recognition of natural plants being lesser of side effect, easily available in surrounding place with low coast. Peptic ulcer disease is one of the common gastrointestinal disorders in clinical practice. The common forms of peptic ulcer are duodenal ulcer, gastric ulcer, NSAIDs induced ulcer and stress ulcer. Gastric ulcers occur commonly at old age and lower socio-economic class of individuals. Many synthetic drugs are used for the treatment of peptic ulcers but cause various adverse effects. Hence herbal medicines stand out as being exceptional for its ethnic, ethno botanical and ethno pharmacological use. In this review attempts have been made to know the antiulcer drug of natural origin with their suggested medicinal part, screening methodology and type of extract used for evaluation and investigation to prove its use. The objective of present review is to compile literature and the antiulcer properties of the most commonly employed herbal medicines.


Peptic ulcer, Antiulcer, Herbal drugs, Phytochemicals

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Vogel HG, Similarities between various systems of traditional medicine: Considerations for the future of ethnopharmacology. J. Ethnopharmacol., 1991, 35: 179-190.

Ramarao AV, Gurjar MK. Drugs from plant resources: an overview. Pharma. Times 1990; 22 (5):19-21.

Handa SS. Plants as drugs. The Eastern Pharmacist 1991; 34 (397): 79-85.

Crawford James M. Pathological Basis of disease, 6th Ed., Robbin (editor), W.B. Saunders Company 2000; 793-796.

Dey N.C. and Dey T.K., A Text Book Of Pathology, 15th ed., New Central Book Agency, Clacutta, 2002, 18.11.

Boyd W., A Text Book Of Pathology Structure and Function in Disease, 8th ed., Lea & Febiger, United Kingdom, 1970, 803.

Satoskar R.S., Bhandarkar S.D. and Ainapure S.S., Pharmacology and Pharmacotherapeu -tics, 18th ed., Popular Prakashan, Mumbai, 2003, 601-616.

Bose Manoj, Motgere, Vijay M, Dakhale, Ganesh N, Tarunkar Avinash. Anti ulcer activity of levcromakalim and Nicorandil in albino rats, a comparative study. Pol J Pharmacol 55: 2003; 91-95.

Sairam KS, Priyambada, Arya NC, Goel RK. Gastroduodenal ulcer protective activity of Asparagus racemosus. An experimental, biochemical and histological study. J Ethnopharmacol 86: 2003; 1-10.

Garrick T, Kolve E, Kauffman GLJR. Prostaglandin requirements are greater for protection in cold restrain induced than alcohol induced gastric mucousal injury. Digest Dis Sci 31: 1986; 401-405.

Ogle CW, Cho CH, Soter Dai. Intragastric NaHCO3 perfusion and vagal-induced ulcer formation in the rat stomach. Eur J Pharmacol 37: 1976; 197-201.

Cho CH, Ogle CW. Cholinergic mediated gastric mast cell degranulation with subsequent histamine H1 and H2 receptor activation in stress ulceration in rats. Eur J Pharmacol 55: 1979; 23-33.

Kitagawa H, Fjuwara M, Osumi Y. Effect of water immersion stress on gastric secretion and mucousal blood flow in rats. Gastroenterol 77: 1979; 298-302.

Perry MA, Wadhwa SDA, Parks W Pickard, Granger DN. Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterol 90: 1986; 362-367.

Itoh M, Guth P. Role of oxygen derived free radicals in hemorrhagic shock induced gastric lesions in the rat. Gastroenterol 88: 1985; 1165-1167.

Salim AS. The significance of removing oxygen derived free radicals in the treatment of acute and chronic duodenal ulceration in the rat. J Pharm Pharmacol 42: 1990; 64-67.

Choudhary MK, Bodakhe SH, Gupta SK. Assessment of the Antiulcer Potential of Moringa oleifera Root-Bark Extract in Rats. J Acupunct Meridian Stud. 2013; 6(4):214-220.

Akuodor GC, Essien AD, David-Oku E, Chilaka KC, Akpan JL, Ezeokpo B, Ezeonwumelu JO. Gastroprotective effect of the aqueous leaf extract of Guiera senegalensis in Albino rats. Asian Pac J Trop Med. 2013; 6(10):771-775

Ishola IO, Awodele O, Oreagba IA, Murtala AA, Chijioke MC. Antinociceptive, anti-inflammatory and antiulcerogenic activities of ethanol root extract of Strophanthus hispidus DC (Apocynaceae). J Basic Clin Physiol Pharmacol. 2013; 9:1-10

Al Batran R, Al-Bayaty F, Jamil Al-Obaidi MM, Abdualkader AM, Hadi HA, Ali HM, Abdulla MA. In vivo antioxidant and antiulcer activity of Parkia speciosa ethanolic leaf extract against ethanol-induced gastric ulcer in rats. PLoS One. 2013; 8(5):e64751.

Burci LM , Pereira IT, da Silva LM, Rodrigues RV, Facundo VA, Milito JS, Santos AR, Marques MC, Baggio CH, Werner MF. Antiulcer and gastric antisecretory effects of dichloromethane fraction and piplartine obtained from fruits of Piper tuberculatum Jacq. in rats. J Ethnopharmacol. 2013; 148(1):165-174.

Ribeiro AR, Diniz PB, Estevam CS, Pinheiro MS, Albuquerque-Jnior RL, Thomazzi SM. Gastroprotective activity of the ethanol extract from the inner bark of Caesalpinia pyramidalis in rats. J Ethnopharmacol. 2013; 147(2):383-388.

Ahmad A, Gupta G, Afzal M, Kazmi I, Anwar F. Antiulcer and antioxidant activities of a new steroid from Morus alba. Life Sci. 2013; 92(3):202-210.

Sakat SS, Tupe P, Juvekar A. Gastroprotective Effect of Oxalis corniculata (Whole Plant) on Experimentally Induced Gastric Ulceration in Wistar Rats. Indian J Pharm Sci. 2012 ;74(1):48-53.

Tamashiro Filho P, Sikiru Olaitan B, Tavares de Almeida DA, Lima JC, Marson-Ascncio PG, Donizeti Ascncio S, Rios-Santos F, Martins DT. Evaluation of antiulcer activity and mechanism of action of methanol stem bark extract of Lafoensia pacari A. St.-Hil. (Lytraceae) in experimental animals. J Ethnopharmacol. 2012; 144(3):497-505.

Hisam EE, Zakaria ZA, Mohtaruddin N, Rofiee MS, Hamid HA, Othman F. Antiulcer activity of the chloroform extract of Bauhinia purpurea leaf. Pharm Biol. 2012; 50(12):1498-507.

Modi KP, Lahiri SK, Goswami SS, Santani DD, Shah MB. Evaluation of antiulcer potential of Mimusops hexandra in experimental gastro duodenal ulcers. J Complement Integr Med. 2012; 10(9):Article 18.

Vijayakumar M, Eswaran MB, Ojha SK, Rao ChV, Rawat AK. Antiulcer Activity of Hydroalchol Extract of Momordica dioica roxb. Fruit. Indian J Pharm Sci. 2011; 73(5):572-577.

Jawanjal H, Rajput MS, Agrawal P, Dange V. Pharmacological evaluation of fruits of Terminalia belerica Roxb. for antiulcer activity. J Complement Integr Med. 2012; 18(9):Article 9.

Bansal VK, Goel RK. Gastroprotective effect of Acacia nilotica young seedless pod extract: role of polyphenolic constituents. Asian Pac J Trop Med. 2012; 5(7):523-528.

Megala J, Geetha A. Antiulcerogenic activity of hydroalcoholic fruit extract of Pithecellobium dulce in different experimental ulcer models in rats. J Ethnopharmacol. 2012; 142(2):415-421.

Zabidi Z, Wan Zainulddin WN, Mamat SS, Shamsahal Din S, Kamisan FH, Yahya F, Ismail NA, Rodzi R, Hassan H, Mohtarrudin N, Somchit MN, Zakaria ZA. Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats. Med Princ Pract. 2012; 21(5):501-503.

Vasudeva N, Sethi P, Sharma SK, Kumar S, Sharma S. Antiulcer potential of the ethanolic extract of Aerva persica Merrill root in rats. J Acupunct Meridian Stud. 2012; 5(2):80-6.

Lemos LM, Martins TB, Tanajura GH, Gazoni VF, Bonaldo J, Strada CL, Silva MG, Dall'oglio EL, de Sousa Jnior PT, Martins DT. Evaluation of antiulcer activity of chromanone fraction from Calophyllum brasiliesnse Camb. J Ethnopharmacol. 2012; 141(1):432-9.

Al-Amin M, Sultana GN, Hossain CF. Antiulcer principle from Zingiber montanum. J Ethnopharmacol. 2012; 141(1):57-60.

Das AK, Bigoniya P, Verma NK, Rana AC. Gastroprotective effect of Achyranthes aspera Linn. leaf on rats. Asian Pac J Trop Med. 2012; (3):197-201.

Prabha P, Karpagam T, Varalakshmi B, Packiavathy AS. Indigenous anti-ulcer activity of Musa sapientum on peptic ulcer. Pharmacognosy Res. 2011; 3(4):232-238.

Raji Y, Oloyede GK. Antiulcerogenic effects and possible mechanism of action of Quassia amara (L. Simaroubaceae) extract and its bioactive principles in rats. Afr J Tradit Complement Altern Med. 2011; 9(1):112-119.

Carvalho CA, Fernandes KM, Matta SL, Silva MB, Oliveira LL, Fonseca CC. Evaluation of antiulcerogenic activity of aqueous extract of Brassica oleracea var. capitata (cabbage) on Wistar rat gastric ulceration. Arq Gastroenterol. 2011; (4):276-282.

de-Faria FM, Almeida AC, Luiz-Ferreira A, Dunder RJ, Takayama C, da Silva MS, da Silva MA, Vilegas W, Rozza AL, Pellizzon CH, Toma W, Souza-Brito AR. Mechanisms of action underlying the gastric antiulcer activity of the Rhizophora mangle L. J Ethnopharmacol. 2012; 139(1):234-243.

Arumugam S, Selvaraj SV, Velayutham S, Natesan SK, Palaniswamy K. Evaluation of anti-ulcer activity of Samanea saman (Jacq) merr bark on ethanol and stress induced gastric lesions in albino rats. Indian J Pharmacol. 2011; (5):586-590.

Lemos M, Santin JR, Jnior LC, Niero R, Andrade SF. Gastroprotective activity of hydroalcoholic extract obtained from the leaves of Brassica oleracea var. acephala DC in different animal

models. J Ethnopharmacol. 2011; 138(2):503-507.

Chanda S, Baravalia Y, Kaneria M. Protective effect of Polyalthia longifolia var. pendula leaves on ethanol and ethanol/HCl induced ulcer in rats and its antimicrobial potency. Asian Pac J Trop Med. 2011; (9):673-679.

Devaraj VC, Krishna BG. Gastric antisecretory and cytoprotective effects of leaf extracts of Amaranthus tricolor Linn. in rats. Zhong Xi Yi Jie He Xue Bao. 2011; 9(9):1031- 1038.

Paula de Oliveira A, Santin JR, Lemos M, Klein Jnior LC, Couto AG, Meyre da Silva Bittencourt C, Filho VC, Faloni de Andrade S. Gastroprotective activity of methanol extract and marrubiin obtained from leaves of Marrubium vulgare L. (Lamiaceae). J Pharm Pharmacol. 2011; 63(9):1230-1237.

Zakaria ZA, Abdul Hisam EE, Rofiee MS, Norhafizah M, Somchit MN, Teh LK, Salleh MZ. In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf. J Ethnopharmacol. 2011; 137(2):1047-1054.

Saranya P, Geetha A. Antiulcer activity of Andrographis paniculata (Burm.f.) wall. against cysteamine-induced duodenal ulcer in rats. Indian J Exp Biol. 2011; (7):525-533.

Mathew OJ, Ogochukwu AM, Michael UC. Antiulcer activity of methanolic extract and fractions of Picralima nitida seeds(Apocynacaea) in rats. Asian Pac J Trop Med. 2011; 4(1):13-15.

Devaraj VC, Gopala Krishna B, Viswanatha GL, Satya Prasad V, Vinay Babu SN. Protective effect of leaves of Raphinus sativus Linn on experimentally induced gastric ulcers in rats. Saudi Pharm J. 2011; 19(3):171-176.

Sathish R, Sahu A, Natarajan K. Antiulcer and antioxidant activity of ethanolic extract of Passiflora foetida L. Indian J Pharmacol. 2011; 43(3):336-339.

Kalra P, Sharma S, Suman, Kumar S. Antiulcer effect of the methanolic extract of Tamarindus indica seeds in different experimental models. J Pharm Bioallied Sci. 2011; 3(2):236-241.

Sharma V, Rajani GP. Evaluation of Caesalpinia pulcherrima Linn. for anti-inflammatory and antiulcer activities. Indian J Pharmacol. 2011; 43(2):168-171.

Sharma P, Prakash T, Kotresha D, Ansari MA, Sahrm UR, Kumar B, Debnath J, Goli D. Antiulcerogenic activity of Terminalia chebula fruit in experimentally induced ulcer in rats. Pharm Biol. 2011; 49(3):262-268.

Kumar A, Singh V, Chaudhary AK. Gastric antisecretory and antiulcer activities of Cedrus deodara (Roxb.) Loud. in Wistar rats. J Ethnopharmacol. 2011; 134(2): 294-297.

Mahattanadul S, Ridtitid W, Nima S, Phdoongsombut N, Ratanasuwon P, Kasiwong S. Effects of Morinda citrifolia aqueous fruit extract and its biomarker scopoletin on reflux esophagitis and gastric ulcer in rats. J Ethnopharmacol. 2011; 134(2):243-250.

Santin JR, Lemos M, Klein-Jnior LC, Machado ID, Costa P, de Oliveira AP, Tilia C, de Souza JP, de Sousa JP, Bastos JK, de Andrade SF. Gastroprotective activity of essential oil of the Syzygium aromaticum and its major component eugenol in different animal models. Naunyn Schmiedebergs Arch Pharmacol. 2011; 383(2):149-158.

Roy S, Niranjan C, Jyothi T, Shankrayya M, Vishawanath K, Prabhu K, Gouda V, Setty R. Antiulcer and Anti-inflammatory Activity of Aerial Parts Enicostemma littorale Blume. J Young Pharm. 2010 Oct;2(4):369-73.

Bucciarelli A, Minetti A, Milczakowskyg C, Skliar M. Evaluation of gastroprotective activity and acute toxicity of Solidago chilensis Meyen (Asteraceae). Pharm Biol. 2010;48(9):1025-1030.

Karthikeyan S, Gobianand K. Antiulcer activity of ethanol leaf extract of Cassia fistula. Pharm Biol. 2010; 48(8):869-877.

Al-Howiriny T, Alsheikh A, Alqasoumi S, Al-Yahya M, ElTahir K, Rafatullah S. Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats. Pharm Biol. 2010; 48(7):786-793.

Alimi H, Hfaiedh N, Bouoni Z, Hfaiedh M, Sakly M, Zourgui L, Rhouma KB. Antioxidant and antiulcerogenic activities of Opuntia ficus indica f. inermis root extract in rats. Phytomedicine. 2010; 17(14):1120-1126.

Banji D, Singh J, Banji OJ, M S. Scrutinizing the aqueous extract of leaves of pedalium murex for the antiulcer activity in rats. Pak J Pharm Sci. 2010; 23(3):295-299.

Joseph JM, Sowndhararajan K, Manian S. Protective effects of methanolic extract of Hedyotis puberula (G. Don) R. Br. ex Arn. against experimentally induced gastric ulcers in rat. J Ethnopharmacol. 2010; 131(1):216-219.

Yesilada E, Gurbuz I. Evaluation of the antiulcerogenic activity profile of a flavonol diglucoside from Equisetum palustre L. J Ethnopharmacol. 2010; 131(1):17-21.

Alam S, Asad M, Asdaq SM, Prasad VS. Antiulcer activity of methanolic extract of Momordica charantia L. in rats. J Ethnopharmacol. 2009; 123(3):464-469.

Massignani JJ, Lemos M, Maistro EL, Schaphauser HP, Jorge RF, Sousa JP, Bastos JK, de Andrade SF. Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats. Phytother Res. 2009; 23(10):1355-13560.

Rachchh MA, Jain SM. Gastroprotective effect of Benincasa hispida fruit extract. Indian J Pharmacol. 2008 Nov;40(6):271-5.



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