Accuracy of diagnosis by Fine Needle Non Aspiration Cytology technique in head and neck swellings.Its advantages and disadvantages in comparison with Fine Needle Aspiration Cytology.

C P Manjula, M Hemalata, Kusuma Venkatesh, Ashok Chidanand Alatgi

Abstract


Background & Objectives:

                        Fine needle aspiration cytology (FNAC) is a first line investigation in the diagnosis of head and neck swellings. The negative pressure applied during aspiration leads to bloody smears, especially in vascular organs like thyroid. In 1981 fine needle non-aspiration cytology (FNNAC) was introduced. The present study was undertaken to compare FNAC and FNNAC techniques in head and neck swellings.

Methods: One hundred and ninety seven head and neck swellings were sampled using both FNAC and FNNAC techniques. They were compared for the five objective parameters, amount of background blood or clots, amount of cellular material present, retention of appropriate architecture, degree of cellular degeneration and degree of cellular trauma, using Mair’s point scoring system. Statistical analysis was done using Mann Whitney’s test. The differences were considered significant at P£0.05.

Results: Blood contamination was less in FNNAC as compared to FNAC in all the cases. The difference was statistically significant in thyroid, lymphnode and salivary gland lesions. Cellular yield was more in FNNAC in thyroid and lymphnode lesions, with a significant difference being noted only in lymphnode lesions. Better retention of architecture with a statistically significant difference was seen in FNNAC smears from lymphnode and thyroid lesions. There was no significant difference between the two techniques in degree of cellular degeneration and cellular trauma. More number of FNNAC smears were diagnostically superior. The diagnostic yield in FNAC was 93.43% and in FNNAC 94.28%.

Conclusion: The FNNAC technique provides adequate cellular yield in all head and neck swellings, except in cystic and fibrotic swellings where FNAC is a better technique.

 


Keywords


Fine Needle Aspiration cytology, Fine needle non aspiration cytology, Thyroid, Lymphnodes, Salivary gland

Full Text:

PDF

References


Orell SR, Sterret GF, Walters Max N-I, Darrel Whitaker D, Ed., Manual and atlas of fine needle aspiration cytology, 3rd edition. London, Churchill Livingstone ; 1999 : 1-9.

Amedee RG, Dhurandhar NR. Fine-Needle Aspiration Biopsy : clinical State of the art review. The Laryngoscope 2001; 111 : 1551-1557.

Zajdela A, Zillhardt P, Voillemot N. Cytological Diagnosis by fine needle sampling without aspiration. Cancer 1987 ; 59 : 1201-1205.

Mair S, Dunbar F, Becker PJ, Plessis WD. Fine Needle cytology – Is aspiration suction necessary ? A study of 100 masses in various sites. Acta Cytol 1989 ; 33 : 809-813.

20. Misra RK, Sharma SP, Nanda A, Rai SP. Diagnostic utility of fine needle sampling without aspiration in comparison to fine needle aspiration in head and neck swellings – A prospective study. Journal of Cytology 2000 ; 17(2) : 103-110

68. Ghosh A, Misra RK, Sharma SP, Singh HN, Chaturvedi AK : Aspiration Vs non-aspiration technique of cytodiagnosis – a critical evaluation in 160 cases. Indian J. Pathol. Microbiol. 2000 ; 43 : 107-112

Braun H, Walch C, Beham A, Moinfar F : Fine needle capillary cytology versus fine needle aspiration cytology – a comparison of quality between puncture techniques in the ENT area. Laryngorhinootologie 1997 ; 76 : 358-363

Akhtar SS, Imran-Ul-Huq, Faiz-U-Din, Reyes LM : Efficacy of fine-needle capillary biopsy in the assessment of patients with superficial lymphadenopathy. Cancer 1997 ; 81 : 277-280

Cajulis RS, Sneige N : Objective comparison of cellular yield in fine-needle biopsy of lymphnodes with and without aspiration. Diagn Cytopathol 1995 ; 12 : 384-385

Kate MS, Kamal MM, Bobhate MK, Kher AV. Evaluation of Fine needle capillary sampling in superficial and deep seated lesions – An analysis of 670 cases. Acta Cytol 1998 ; 42 : 679-684.

Kamal MM, Arjune DG, Kulkarni HR: Comparative study of fine needle aspiration and fine needle capillary sampling of thyroid lesions. Acta Cytol 2002 ; 46 : 30-34.

Jayaram G, Gupta B : Non-aspiration fine needle cytology in diffuse and nodular thyroid lesions : A study of 220 cases. Acta Cytol 1991 ; 789-790

Santos Jose’ EC, Leiman G. Nonaspiration fine needle cytology : Application of a new technique for nodular thyroid disease. Acta Cytol 1988 ; 32 : 353-356.




DOI: http://dx.doi.org/10.7439/ijbr.v8i5.4162

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Refbacks

  • There are currently no refbacks.




Copyright (c) 2017 International Journal of Biomedical Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.