GREEN SYNTHESIS AND ANTIHYPERTENSIVE ACTIVITY OF SOME MANNICH BASES OF 1, 4 DIHYDROPYRIDINE COMPOUNDS

Pravin Jadhav, Rohini R. Pujari, N. R. Chatterjee

Abstract


Some new Mannich Bases of 1, 4 Dihydropyridine derivatives were synthesised by reaction of 1, 4 Dihydropyridine derivatives formaldehyde (HCHO) & secondary amines (e.g. morpholine, 1-methyl piperazine) in 1:1 ratio under acidic condition in presence of trace HCl. The compounds synthesised were identified by UV, 1H NMR, and FT-IR spectroscopic techniques. All compounds studied in this work were screened for their antihypertensive activity by against DOCA salt induced hypertension.


Keywords


antihypertensive activity; 1, 4 Dihydropyridines; Mannich bases; green synthesis

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DOI: https://doi.org/10.7439/ijbr.v3i7.132

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