QSAR study of some new 2, 5-disubstituted 1, 3, 4-oxadiazole derivatves as anti-microbial and anti-inflammatory agents

Nachiket S. Dighe, Deepak S. Musmade, Trupti Sahane, Pankaj Shinde, Govind S. Asane

Abstract


 The synthesis, structure and biological activity of Oxadiazole derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Oxadiazole derivatives have been reported to possess interesting biological activities such as Antimicrobial, Anti-inflammatory and Antifungal activities etc. Around 09 new derivatives were synthesized, with the standard chemicals and well established procedures. The synthesized compounds were tested for their preliminary tests, physical constants, TLC etc. IR, 1H-NMR Spectra and CHN analysis confirmed the structures of the final compounds. The proposed compounds were screened for their antimicrobial and anti-inflammatory activities with the standard drugs in the well-equipped microbiology and pharmacology lab by using standard methods.


Keywords


Anti-inflammatory, Antimicrobial and Oxadiazole

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DOI: http://dx.doi.org/10.7439/ijpc.v4i4.103

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