synthesis and characterization of 2-methoxy-6-phenyl-5h-pyrrolo[3,4-b]pyrazine-5,7(6h)-dione and 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5h-pyrrolo[3,4-b]pyrazine-5-one and some derivatives

Keerti Saraswat, Shashi Kant Pandey

Abstract


The process of producing a series of chemical combinations of 2-methoxy-6-phenyl-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione descendant [103-110] and 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-one descendant [111-119], magnetized significant regard in prospective of curative requisition. The  fusion  was conved by conducting 2-hydroxyfuro [3,4-b]pyrazine-5,7-dione with equimolar Bromomethane in dry toluene at 0-5°C to get combination 2-methoxyfuro[3,4-b]pyrazine-5,7-dione which further at reflux condense with aniline derivatives to 2-methoxy-6-phenyl-5H-pyrrolo[3,4-b]pyrazine-5,7(6H)-dione derivatives with Potassium borohydride granules in methanol at 0-20°C converted to 7-hydroxy-3-methoxy-6-phenyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine-5-one descendant. The distinctive nature of all the incorporated combinations have been described by manipulating basic inspection (elemental analysis), IR, 1H NMR, 13C NMR spectroscopical.


Keywords


Descendant; equimolar; incorporated; manipulating; granules.

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DOI: http://dx.doi.org/10.7439/ijpc.v7i8.4267

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