Tumor inhibitory activity of methanolic and ethyl acetate soluble extracts of Thuja occidentalis L. on mice bearing Ehrlich ascites carcinoma.

Archana M Navale, Gaurang B Shah, Anand B Pithadia

Abstract


Thuja occidentalis (Cupressaceae) is an ornamental plant of European origin. It has been used in folk medicine for the treatment of cancer. Mice bearing Ehrlich Ascites Carcinoma (EAC mice) were treated with methanolic extract (165 mg/kg), ethyl acetate soluble fraction (30 mg/kg) and combination of both extracts of TO. Inhibition of tumor growth, increase in survival time of animal with treatment, and hematological parameters were determined. Both methanolic and ethyl acetate soluble fractions of TO exerted tumor growth inhibitory activity in mice bearing EAC. Combination treatment of two extracts showed more pronounced effect. In conclusion, Methanolic and ethyl acetate soluble extracts of TO exhibit anticancer activity against Ehrlich ascites carcinoma in mice. Thus, it has anticancer potential and should be further evaluated in higher models.


Keywords


Thuja occidentalis, Ehrlich ascites carcinoma, antitumor, mice

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DOI: http://dx.doi.org/10.7439/ijpp.v4i3.91

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