A comparative trial on the efficacy of vitamin c as add on therapy to the oral hypoglycemic agent on serum lipid level in newly diagnosed type 2 diabetes mellitus

Rekha Nayaka M.R.

Abstract


Background: Diabetic patients are more prone to develop cardiovascular diseases due to rise in blood glucose and serum cholesterol level. There will be elevated free radicals and decreased antioxidants like vitamin C level in these patients. Vitamin C has shown beneficial effect in controlling serum lipids and blood glucose level.

Aim: to study the effect of different doses of Vitamin C on serum lipid level

Methods: A total of 90 patients with newly diagnosed type 2 diabetes referred to Government Hospital, Chennai, India, were included in the study. Patients were divided into 3 groups. They received randomly glibenclamide 5mg, glibenclamide 5mg with vitamin C 1g and   glibenclamide 5mg with vitamin C 2g orally for 8-weeks. Investigations like Fasting blood sugar (FBS), Postprandial blood sugar (PPBS), Lipid profile: LDL, HDL, TG, TC were measured before and after vitamin C consumption and the results were analyzed.

Results: Significant   increase in  HDL  level (p<0.01)seen in group supplemented with vitamin C 2g  when compared  to group supplemented with vitamin c 1gm at the end of 8th week. There was significant reduction in TG, LDL and TC level in each group at the end of 8th week but no significant difference in between the groups.

Conclusions: Vitamin C in a dose of 2g/day as add on therapy to oral hypoglycemic agent produces   improvement in lipid profile to the desirable levels and thus reducing the risk of diabetic complications.


Keywords


Vitamin C; type 2diabetic mellitus;Serum lipids

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References


Afkhami-Ardekani M, Vahidi AR, Borjian L, Borjian L. Effect of vitamin C supplement on glycosilated hemoglobin in patients with type 2 diabetes. J Shah Sad University 2003:10:15-8.

Tierney L M, McPhee S J, Papadakis M A. Current medical Diagnosis & Treatment. International edition. New York: Lange Medical Books/McGraw Hill, 1203-1215.

Rother, Kl "Diabetes Treatment-Bridging the Divide". New England Journal of Medicine 2007; 356(15): 1499-1501.

Sartoskar RS, Bhandarker SD, and Nirmala, Pharmacology and Pharmacotherapeutics, 20th Edition., Popular Prakasan, Mumbai, India, 2007. Pg no:871 -900.

Von Mehring J, Minkowski O. "Diabetes mellitus nach pankreasexstirpation.". Arch Exp Pathol Pharmakol 1890; 26:371-387.

Seidell JC "Obesity, insulin resistance and diabetes-a worldwide epidemic". British Journal of Nutrition. 2000; 83 Suppl 1: S5-8.

Ramachandaran A, Snehalatha C, Vijay V.Explosion of type 2 Diabetes in the Indian subcontinent. International Diabetes Moniter 2003; 15:1-6.

Ramachandaran A, Snehalatha C, Baskar et al. Temporal changes in prevalence of diabetes and impaired glucose tolerance associated with life style transition occurring in rural population of India. Diabetologica 2004; 47:860-863.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030". Diabetes Care 2004; 27(5): 1047–53.

"Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications" WHO,

Journal from June 14, 2006, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences & Health Services, Yazd, Iran.

Forghani B, Goharian V, Kassayian N, Amini M. The effect of vitamin C supplements on serum lipoprotein levels in NIDDM patients. J M C Isfahan Univ 2001; 2: 95-100.

Errikson J, Kahvakka A. Magnesium and ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab 1995; 39: 217-23.




DOI: http://dx.doi.org/10.7439/ijpr.v5i4.1961

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