Recent advances in bone marrow transplantation in the treatment of leukemia

Arshiya Tabbasum, Asif Rasheed, Maryam Fatima


Bone marrow is a greasy, vascular tissue that fills most bone depressions and is outcome of red blood cells (RBC) and white blood cells (WBC). Blood diseases, regenerative treatment, autoimmune diseases, repairing brain damage haematological clutters can be readily treated by bone marrow transplantation. There are two major types of bone marrow transplants. The type used will depend on the reason you need a transplant they are: Autologous transplants, Allogenic transplants. Autologous transplants include the utilization of a man's own foundational microorganisms. Lessened power transplants are done on an inpatient or outpatient premise contingent upon the treatment arrange. Bone marrow transplant is needed to cure Aplastic fraility, leukemia, lymphoma, mylenoma, autoimmune diseases, acquired metabolic diseases, hodgkin disease and sickle cell anemia.The following diseases are the one of the most benefit treated from bone marrow transplant: Leukaemias, Severe aplastic anaemia, Lymphomas, Multiple myeloma Immune deficiency disorders. Recent advances in treatment of leukemia other than bone marrow transplantation includes treatment of Some solid tumour cancers bone marrow transplants without using chemotherapy The chemotherapy and radiation used for transplant damage DNA and can cause both immediate problems and long-term damage to many tissues in the body. Using antibodies such as Attaching the antibody to c-kit resulted in depletion of blood stem cells in immune-deficient miceT-cell depletion, By increasing the number of T cells given in each treatment in a controlled manner, they hope to identify desired effect on leukaemia cells without causing significant graft-versus-host disease, Engineered t- cell to train a patients T-cells to recognize and kill cancer cells, reduced-intensity conditioning regimens which are better tolerated because they utilize lower doses of chemotherapy and/or radiation therapy and recently innovated therapy is invivo imaging using bioluminescence which is a tool for probing graft-versus-host disease


Autoimmune disease, Leukaemia, Allogenic, Lymphomas, Bioluminescence

Full Text:



Advances In Bone Marrow Transplantation Improve Safety By Sara Latta | December 8, 1997

Birbrair, Alexander; Frenette, Paul S. (2016-03-01). "Niche heterogeneity in the bone marrow". Annals of the New York Academy of Sciences. 1370: 8296. doi:10.1111/nyas.13016.ISSN 1749-6632.

Raphael Rubin & David S. Strayer (2007). Rubin's Pathology: Clinicopathologic Foundations of Medicine. Lippincott Williams & Wilkins. p. 90. ISBN 0-7817-9516-8.

The Lymphatic System. Retrieved 5 December 2011.

Human Tissue Sample Blog The Importance of Bone Marrow Adult Stem Cells in Medicine Posted by Luke Doiron on Oct 28, 2014 6:00:00 AM

Hocka p, Wagner: Blood Donation In Bone Marrow Transplantation.

Brian Krans Medically Reviewed by Jeanne Morrison, PhD, MSN on 04 February 2016

Patel JP, Gnen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute

myeloid leukemia. N Engl J Med. 2012; 366(12): 1079-1089. Bone Marrow Transplant

Dreyling M, Ferrero S, Hermine O. How to manage mantle cell lymphoma. Leukemia. 2014; 28(11): 2117-2130. Access

Boyle JM, Buckley RH. Population prevalence of diagnosed primary immunodeficiency diseases in the United States. J Clin Immunol. 2007; 27(5): 497-502.

National Marrow Donor Program. HLA matching: finding the best donor or cord blood unit. Available at Accessed December 12, 2012.

Spellman SR, Eapen M, Logan BR, et al. A perspective on the selection of unrelated donors and cord blood units for transplantation. Blood. 2012;120(2):259-265.

Appelbaum FR, Forman SJ, Negrin RS, Blume KG, eds. Thomas Hematopoietic Cell Transplantation. 4th ed. Oxford, England: Blackwell Publishing Ltd; 2007.

Jagasia MH, Arora M, Flowers ME, et al. Risk factors for acute GvHD and survival after hematopoietic cell transplantation. Blood. 2011;119(1):296-307.

Lowsky R, Negrin RS. Principles of hematopoietic cell transplantation. In: Lichtman MA, Kipps TJ, Seligsohn U, Kaushansky K, Prchal JT, eds. Williams Hematology. 8th ed. Available at AccessMedicine. Accessed December 15, 2012.

Majhail NS, Rizzo JD, Lee SJ, et al. Recommended screening and preventive practices for long-term

survivors after hematopoietic cell transplantation. Bone Marrow Transplantation. 2012;47(3):337-341.

National Marrow Donor Program, Key Messages, Facts & Figures. Updated January 2012. Available at: Figures_%28PDF%29.aspx. Accessed December 15, 2012.

Bone Marrow (Stem Cell) Transplant for Sickle Cell Disease 1 Produced by St. Jude Childrens Research Hospital Departments of Hematology, Patient Education, and Biomedical Communications. Funds were provided by St. Jude Childrens Research Hospital, ALSAC, and a grant from the Plough Foundation.

Tyndall A, Gratwohl A. Haemopoietic stem and progenitor cells in the treatment of severe autoimmune diseases. Ann Rheum Dis 1996;55:149-51.

Knaan-Schanzer S, Houben P, Kinwell-Bohre E, Van Bekkum DW. Remission induction of adjuvant arthritis in rats by total body irradiation and autologous bone marrow transplantation. Bone Marrow Transplant 1991;8:333-8.

Marmont AM. Autoimmunity and allogeneic bone marrow transplantation. Bone Marrow Transplant 1992;9:1-3

McKendry RJR Huebsch L. Progression of rheumatoid arthritis following bone marrow transplantation (BMT). Arthritis Rheum 1994;37(suppl ACR meeting):Abstract 924.

Shimian Zou,1 Simone Glynn,1 Daniel Kuritzkes,2 Monica Shah,1 Nakela Cook,1 and Nancy Berliner,2 for the NHLBI AIDS Blood Session Working Group Shimian Zou,1 Simone Glynn,1 Daniel Kuritzkes,2 Monica Shah,1 Nakela Cook,1 and Nancy Berliner,2 for the NHLBI AIDS Blood Session Working Group

A. Chhabra, A. M. Ring, K. Weiskopf, P. J. Schnorr, S. Gordon, A. C. Le, H.-S. Kwon, N. G. Ring, J. Volkmer, P. Y. Ho, S. Tseng, I. L. Weissman, J. A. Shizuru. Hematopoietic stem cell transplantation in immunocompetent hosts without radiation or chemotherapy. Science Translational Medicine, 2016; 8 (351): 351ra105 DOI: 10.1126/scitranslmed.aae0501

Soci G, Schmoor C, Bethge WA, et al. Chronic graft-versus-host disease: long-term results from a randomized trial on GVHD prophylaxis with or without antiT cell globulin ATG Fresenius. Blood 2011;117(23):6375-6382.

Robert S. Negrin & Christopher H. Contag In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease


Copyright (c) 2017 International Journal of Pharmacological Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.