Effects of Arabusta coffee on the cardiovascular and biochemical parameters in hypertensive rats

Cassime Tiémoko, Alain Dit Philippe Bidie, Gervais M’boh, Allico Joseph DJAMAN


The objective of this investigation is to valorizeArabusta, an hybrid coffee, by testing it on the cardiac and biochemical parameters of rats made hypertensive to adrenaline.The present study was carried out on 32 rats divided into 2 lots: one control (4) and one test (28). After induction of adrenaline hypertension in the test batch, the curative effect of the coffee extract was evaluated at the different doses (200 and 400 mg / kg). At the end of the experiment, the cardiovascular parameters were measured and blood samples were taken for the determination of the various parameters.Our results showed that the treatment of hypertensive rats with the extract at the dose of 400 mg / kg exerted an antihypertensive effect by a significant decrease (P <0.05) of the cardiovascular parameters (-31.2 mmHg for SBP and -31 mmHg for DBP). The beneficial effects of the extract on blood pressure were accompanied by a reduction in oxidative stress.Arabusta coffee could be recommended as a new antihypertensive food supplement because of its remarkable action on some risk factors for the onset of the disease.


Oxidative stress;Blood pressure;Coffee

Full Text:



BoladIandDelafontaineP. Endothelial dysfunction: its role in hypertensive

coronary disease. Curr.Opin.Cardiol. 2005; 20:270-274.

Zemel MB, HilpertKF, WestSG,BagshawDM,FishellV, BarnhartL,LefevreM, MostMM, ChowM,HinderliterAL, Kris-EthertonPM.Effects of dairy

products on intracellular calcium and blood pressure in adults with essential hypertension.

J. Am. Coll. Nutr.2009;28:142-149.

MunzelT, SinningC, PostF,WarnholtzA, SchulzE. Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction. Ann. Med. 2008; 40:180-196.

DickinsonHO, MasonJM, NicolsonDJ, CampbellF,BeyerFR, CookJV, Williams

B, FordGA. Lifestyle interventions to reduce raised blood pressure: a systematic review of randomized controlled trials. J. Hypertens. 2006; 24(2):215-33. Review.

Suzuki A, Kagawa D, Fujii A,Ochiai R, Tokimitsu I, SaitoI. (2002).Short and long-

term effects of ferulic acid on blood pressure in spontaneously hypertensive rats. Am. J.

Hypertens.15: 351-357.

Saito I, Tsuchida T, Watanabe T.Effect of coffee bean extract in essential

hypertension. Jpn J. Med. Pharm. Sci.2002; 47: 67-74.

Ochiai R, Jokura H, Suzuki A. Green coffee bean extract improves human

vasoreactivity. Hypertens.Res. 2004; 27: 731-737.

OlthofMR, HollmanPC, MichelN.Chlorogenic acid, quercetin-3-rutinoside

and black tea phenols are extensively metabolized in humans. J. Nutr.2003; 133: 1806-1814.

SwalesJD. Manual of Hypertension, 1stedn.Blackwell Science Ltd, London. 1995; 32-36.

VanhouttePM and BoulangerCM. Endothelium-dependent responses in hypertension. Hypertens.Res. 1995; 18: 87-98.

Abdo AE, Hesham HS., Mohamed NA, andSaleh MI. Impact of different preparations of coffee on bodyweight, serum uric acid and liver enzymes in experimental rats. Merit Research Journal of Medicine and Medical Sciences. 2015 ; 3(7) 292-300

Umang JH, Tejas GH, TusharbinduDeR, PravinR &Tirgar.Evaluation of

antihypertensive activity of evolvulusalsinoidesin adrenaline induced hypertensive rats.

International Journal Pharmacologie Science4.2012; 194-198.

TiekpaWJ, KoutouA, BahiC, N’guessanJD and CoulibalyA.Evaluation of the effect of “wakouba'' on the lipid profile, systolic blood pressure, diastolicand blood glucose in hypertensive rabbits. Int. J. of Appl. Biol.AndPharm.Techn.2014; 5(4): 87-95.

WeissJ, TaylorGR, ZimmermannFandNebendahl K..Collection of body

fluids- In: KRINKE G.J. The laboratory Rat, The handbook of experimental Animal.

Academic press. 2000; 25: 485-495.

AebiH..Catalase in vitro.MethodsEnzymol.1984; 105:121-6.

FermorB, WeinbergJB, PisetskyDS, MisukonisMA, BanesAJ, GuilakF.

The effect of static and intermittent compression on nitric oxide production in articular

cartilage explants. Journal of Othopaedic Research.2001; 19: 729-737.

GallenIW, RosaRM, EsparazDY, Young JB, Robertson GL, Batlle D, Epstein

FH, Landsberg L. On the mechanism of the effects of potassium restriction on

blood pressure and renal sodium retention. Am. J. Kidney Dis. 1998; 31:19-27.

RangHP, DaleMM, RitterJM, FlowerRJ,Henderson G. Rang and Dale’s

Pharmacology, 7th ed., Elsevier ChuechillLivingstone, Spain.2012; 251-259, 266-70.

SalvadorM, AmarJ. Que penser de l’hypertension diastolique?Annale de

cardiologie et d’Angiologie. 1995; 44 : 543-546.

SuzukiA, YamamotoN, JokuraH, YamamotoM, FujiiA, TokimitsuI,SaitoI.Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J. Hypertens.2006; 24: 106 5– 1073.

ArdiansyahY, OhsakiH, ShirakawaT, Koseki KM. Novel effects of a singleadministration of ferulic acid on the regulation of blood pressure and the hepatic lipid

metabolic profile in stroke-prone spontaneously hypertensive rats. J. Agric. Food Chem. 2008

: 2825–2830.

Actis-Goretta L, Ottaviani JI, Fraga CG. Inhibition of angiotensin converting enzyme activity by flavanol-rich foods.J. Agric. Food Chem.2006; 54:229–234.

GirerdX, Digeos-HasnierS et Le HeuzeyJ-Y. Guide pratique del’hypertension artérielle.Editions Médicales Spécialisées, Paris. 1998; 246 pp.

CohenY. Abrégés de Pharmacologie. 4ème Ed. Révisée. Masson, Paris.1997; 451pp.

Michiru H &Quentin JP.Nifedipine facilitates neurotransmitter release independently of calcium channels. Proc. Natl. Acad. Sci. 2003;100 (10): 6139-6144.

JuanCC, FangVS, HsuYP, HuangYP, HsiaDB, KwokCF, HoL T. Over expression of vascular endothelin-1 and endothelin-A receptors in a fructose-induced

hypertensive rat model. Journal ofhypertension.1998; 16 : 1775-1782.

BoulimiéA, BauemarrsachsJ, LinzW, ScholkensBA, WiemerG, flemingI, Busse

R.Endothelialdisfunction coincides with an enhanced nitric oxide synthetaseexpression and superoxide anion production. Hypertension. 1997; 30 : 934-941.

Sato Y, Itagaki S, Kurokawa T, Ogura J, Kobayashi M, Hirano T, Sugawara

M, Iseki K.In vitro and in vivo antioxidant properties of chlorogenic acid

andcaffeic acid. Int. J. Pharm.2011; 403: 136-8.

DOI: http://dx.doi.org/10.7439/ijpr.v7i10.4437

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


  • There are currently no refbacks.

Copyright (c) 2017 International Journal of Pharmacological Research

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.