DOI:
Keywords:
Anti cancer, Toxicity
Abstract
Objective: In the present study Hepatoprotective activity of Ethanolic Extract of flower of Nymphaea alba Linn were investigated. Material and Method: The hepatoprotective activity of Ethanolic Extract of flower of Nymphaea alba were evaluated by Carbon Tetra Chloride and Paracetamol induced hepatotoxicity in experimental rats. The Etnanolic Extract of Nymphaea alba (200 and 400 mg/kg) treat the hepatotoxicity and produced significant inhibition in the wet liver weight and wet liver volumes and the serum enzymes (SGOT, SGPT and ALP), bilirubin and cholesterol levels. Result: Preliminary phytochemical analysis of Ethanolic Extract of Nymphaea alba revealed that the presence of various phytoconstituents Alkaloids, Carbohydrates (Polysaccharides), Glycosides, Steroids, Flavonoids and Tannin and Phenolic compound. The ethanolic extract (200 and 400 mg/kg) showed significant reduction in SGOT, SGPT, ALP, Bilirubin and cholesterol level as compared to control group. Maximum inhibition was obtained at dose 400 mg/kg of Ethanolic Extract of Nymphaea alba in both model. Conclusion: The present study suggests that Ethanolic Extract of flower of Nymphaea alba Linn possess strong and potential Hepatoprotective activity in both model. So it has immense scope as an effective source to develop drug for the treatment of liver related diseases. These results may further suggest that ethanolic extract was found to possess hepatoprotective activity.
Downloads