Formulation and Development of Aceclofenac Loaded Microsponges for Topical Delivery Using Quality by Design Approach
AbstractMany of marketed conventional dosage forms have quick drug absorption and more dosing frequency thorugh skin. Hence, necessity demands for delivery systems to enhance retention of drug either on skin surface or within the epidermis with reduction of transdermal penetration. The microsponge-based polymeric microspheres can be used frequently for topical which gives another possibility to advance drug products to provide a API effectively at least dose and to improve stability, diminish side effects and amend drug release. Conventional marketed gel proposed to act on outer layers of the skin which may release API on application and produce a very much concentrated layer which may be quickly absorbed. Hence the necessity subsists to exploit on quantity of period that drug which can present inside the epidermis, while lessening its transdermal penetration keen on the body. The concentration of the polymer required to produce microsponges with good physical and morphological characteristics was found to be 11.0% and 13% w/v of the internal phase for both the polymers. The minimum concentration of the emulsifier PVA required to produce microsponges was found to be 0.75% w/v. . From the results it can be concluded that the microsponges Topical Gel could sustain the drug release over a period of 8 hours when compared to the 96% release after 6 hrs from the pure Aceclofenac. By model fitting of the data obtained from the drug release profile we can conclude that drug release mechanism was Higuchi (Matrix) Model.
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Patel U, Shah C, Patel H. Formulation and Development of Aceclofenac Loaded Microsponges for Topical Delivery Using Quality by Design Approach. IJAP [Internet]. 30Apr.2018 [cited 19Apr.2019];7(4):17-2. Available from: https://ssjournals.com/index.php/ijap/article/view/4848
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