UV Spectrophotometric Method For The Estimation of Seratrodast in Bulk and Pharmaceutical Dosage Form
AbstractA simple, specific, accurate and precise U.V Spectroscopy method was developed and validated for the estimation of Seratrodast in pharmaceutical dosage forms. The stock solution was prepared by weighing 100 mg of Standard Seratrodast in 100ml volumetric flask containing distilled water. The final stock solution was made to produce 1000 µg/ml with Methanol. Further dilutions were prepared as per procedure. The linearity was found in the concentration range of 2.5-25 µg/ml. The Correlation coefficient was 0.999. The regression equation was found to be Y = 0.039x + 0.018. The method was validated for linearity, accuracy, precision, limit of detection, limit of quantitation, and ruggedness. The limit of detection and limit of quantitation for estimation of Seratrodast was found to be 0.169 µg/ml and 0.717 µgml respectively. Recovery of Seratrodast was found to be in the range of 99.1-100.5%. Proposed method was successfully applied for the quantitative determination of Seratrodast in pharmaceutical dosage forms.
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