C - reactive protein As An Immunopathological Prognostic Marker For Giardia Lamblia And Entamoeba Histolytica Associated Diarrhea Among Children Of Baghdad Governorate

  • Ali Ibrahim Ali Al-Ezzy Department of Pathology, College of Veterinary Medicine- Diyala University
  • Walaa Najm Abood Department of Medical microbiology and Immunology - Diyala University
  • Rawaa Abulkhaleq Hussein Department of Medical microbiology and Immunology - Diyala University
Keywords: CRP, G.lamblia, E.histolytica, diarrhea


Background: C-reactive protein (CRP) is one of the classic acute phase proteins. The study of induction of acute phase reactants synthesis in parasitic infections would aid in understanding the host –parasite relationship.

Methods: Seventy-three children with parasitic diarrhoea that proved through clinical and microbiological investigation were selected. Thirteen of selected children were infected with G. lamblia and the rest sixty were infected with E. histolytica. Nineteen of the control group was females while the rest eleven were males. Venous Blood were collected from patients and control group for detection of CRP level via latex agglutination test. 

Results: The high rate of infection was detected among the age group (19-36) months. The highest level of CRP was (192 mg/dl) while the lowest one was (12 mg/dl) with a mean level (51.20 mg/dl). The mean level of CRP in control group was (3.7500 mg/dl). Positive significant correlations between CRP level and the age of infected children (r=0.290, p=0.013), the chronic infection with G.lamblia and E. histolytica (r=0.760, p=0.000). Positive significant correlation between the age group and the chronic infection with G. lamblia and E. histolytica (r=0.493, p=0.000).  Significant difference was detected between the patients group and control group regarding the CRP level (p>0.05).

Conclusion: This study proved that CRP level was increased in association with the age and chronic presentation of diarrhoea caused by  G.lamblia and E.histolytica and can be used as a non specific immunological marker for monitoring of clinical presentation of G.lamblia and E.histolytica  associated diarrheal.


Download data is not yet available.


Clark TWM Marie-Jo, Batham, Sally; Curran Martin D, Parmar Surendra, Nicholson Karl G,. C-reactive protein level and microbial aetiology in patients hospitalised with acute exacerbation of COPD. European Respiratory Journal 2014: erj00922-2014.

Safi S. Acute Phase Proteins - Analysis, Clinical Applications and Potentials, Inflammatory Diseases - Im-munopathology, Clinical and Pharmacological Bases,. 2012.

Epstein FH, Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. New England Journal of Medicine1999; 340: 448-54.

Macy EMH, Timothy E; Tracy, Russell P,. Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications. Clinical chemistry 1997; 43: 52-8.

Gasim S, Theander TG, ElHassan AM. High levels of C-reactive protein in the peripheral blood during vis-ceral leishmaniasis predict subsequent development of post kala-azar dermal leishmaniasis. Acta tropica 2000; 75: 35-8.

Mahon CR, Flaws ML. Host-Parasite Interaction. 2014: 23 p.

Chernecky CCB, Barbara J,. Laboratory tests and diagnostic procedures. Elsevier Health Sciences, 2007.

Mehlhorn H. Encyclopedic Reference of Parasitology, Biology, Structure, Function.Springer Ltd., 2001.

SPINREACT. Qualitative determination of C-Reactive Protein (CRP),CRP-Latex Slide agglutination avail-able from:www.spinreact.com

AL-Ezzy AIA, Abood WN. Immuno-Microbiological Diagnosis of Co-Infections with Rota Virus, Giardia lamblia, Entamoeba histolyticaand Salmonella entericaas a Possible pathological strategy for acute diar-rheal among Iraqi Children. International Journal of Advanced Research 2013; 1: 216-24.

Abood WN, Al-Ezzy AIA. Possible correlation between O-antigen serogroup of Enteropathogenic / Entero-invasive E.coli and co infection with Giardia G.lamblia and Entamoeba histolytica as a possible pathological strategy for acute diarrhoea among children of Baghdad governorat. Diyala Journal for Pure Sciences 2010; 6: 205-26.

Gorczynski RaS, J. Clinical Immunology. Land bioscience Ltd., 1999.

How to Cite
Al-Ezzy, A. I., Abood, W., & Hussein, R. (2015). C - reactive protein As An Immunopathological Prognostic Marker For Giardia Lamblia And Entamoeba Histolytica Associated Diarrhea Among Children Of Baghdad Governorate. International Journal of Advances in Scientific Research, 1(1), 33-37. https://doi.org/10.7439/ijasr.v1i1.1713
Research Articles