Absorbance Correction Method for Simultaneous Estimation of Nifedipine and Metoprolol Succinate in Their Synthetic Mixture Using From Spectrophotometry

  • Sojitra Rajanit Department of Quality Assurance, Shree Dhanvantary Pharmacy College, KIM [East], Near Railway Station, Dhanvantary College Road, Taluka: Olpad, Dist: Surat, Gujarat
  • Paras Virani Department of Quality Assurance, Shree Dhanvantary Pharmacy College, KIM [East], Near Railway Station, Dhanvantary College Road, Taluka: Olpad, Dist: Surat, Gujarat
  • Hashumati Raj Department of Quality Assurance, Shree Dhanvantary Pharmacy College, KIM [East], Near Railway Station, Dhanvantary College Road, Taluka: Olpad, Dist: Surat, Gujarat
Keywords: Spectroscopic method, absorption corrected method, Nifedipine and Metoprolol Succinate.

Abstract

A new simple, economical, precise and accurate method are described for the simultaneous determination of Nifedipine (NIF) and Metoprolol Succinate (MET) in combined tablet dosage form. The proposed method was applied for the determination of Nifedipine and Metoprolol Succinate in synthetic mixture, for determination of sampling wavelength, 10?g/ml of each of NIF and MET were scanned in 200-400 nm range and sampling wavelengths were 313nm for NIF and 275.40nm for MET are selected for development and validation of absorption correction method. For this method linearity observed in the range of 5-25?g/ml for NIF and 25-125?g/ml for MET, and in their pharmaceutical formulation with mean percentage recoveries 100.68 and 100.33, respectively. The method was validated according to ICH guidelines and can be applied for routine quality control testing.

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Published
2015-04-30
How to Cite
Rajanit, S., Virani, P., & Raj, H. (2015). Absorbance Correction Method for Simultaneous Estimation of Nifedipine and Metoprolol Succinate in Their Synthetic Mixture Using From Spectrophotometry. International Journal of Advances in Scientific Research, 1(3), 151-155. https://doi.org/10.7439/ijasr.v1i3.1774
Section
Research Articles