Nasal Drug Delivery: A Potential Route for Brain Targetting

  • Brahmaiah Bonthagarala Department of Pharmaceutics, SIMS College of Pharmacy, SIMS Group of Institutions, Mangaldas Nagar, Guntur-522001, Andhra Pradesh,
  • Shabana P. Department of Pharmaceutics, SIMS College of Pharmacy, SIMS Group of Institutions, Mangaldas Nagar, Guntur-522001, Andhra Pradesh,
  • Abbaraju Lakshmi Harini Department of Pharmaceutics, SIMS College of Pharmacy, SIMS Group of Institutions, Mangaldas Nagar, Guntur-522001, Andhra Pradesh,
  • Varun Dasari Department of Pharmaceutics, K.C Reddy Institute of Pharmaceutical Sciences, Jangamguntlapalem Post,MedikonduruMandal, Guntur Dist. - 522 348, Andhra Pradesh
Keywords: Nasal Delivery, Brain targeting, Blood-Brain barrier (BBB), Central nervous system (CNS), Cerebrospinal fluid (CSF).

Abstract

Present review highlights the potential of nasal mucosa as an administration route for targeting the central nervous system, the brain. Targeted drug delivery seeks to concentrate the medication in the tissues of interest while reducing the relative concentration of medication in the remaining tissues. Thus improving efficacy of the drug and reducing side effects. The nasal mucosa when compared to other mucousmembranes is easily accessible and provides a practical entrance portal for small and large molecules.Intranasal administration offers rapid onset of action, no first-pass effect, no gastrointestinal degradationor lung toxicity and non-invasiveness application and also improves bioavailability. It is thought thatolfactory route of drug transport, by pass the blood-brain barrier and allows the direct transport of drugfrom the nose to the brain. This review provides an overview of strategies to improve the drug delivery to brain via nasal mucosa and recent advances in this field.

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Published
2015-04-01
How to Cite
Bonthagarala, B., P., S., Harini, A., & Dasari, V. (2015). Nasal Drug Delivery: A Potential Route for Brain Targetting. International Journal of Advances in Scientific Research, 1(2), 65-70. https://doi.org/10.7439/ijasr.v1i2.1782
Section
Review Articles