Zero order and area under curve spectrophotometric methods for determination of Levocetirizine in pharmaceutical formulation
Simple, fast and reliable spectrophotometric methods were developed for determination of Levocetirizine in bulk and pharmaceutical dosage forms. The solutions of standard and the sample were prepared in methanol. The quantitative determination of the drug was carried out using the zero order derivative values measured at 230 nm and the area under the curve method values measured at 227-234 nm (n=2). Calibration graphs constructed at their wavelengths of determination were linear in the concentration range of Levocetirizine using 5-25μg/ml (r²=0.998 and r²=0.999) for zero order and area under the curve spectrophotometric method. All the proposed methods have been extensively validated as per ICH guidelines. There was no significant difference between the performance of the proposed methods regarding the mean values and standard deviations. Developed spectrophotometric methods in this study are simple, accurate, precise and sensitive to assay of Levocetirizine in tablets.
Sunil R. Dhaneshwar, Kumudini S. Rasal, Vidhya K. Bhusari, Janaki V. Salunkhe and Amruta L. Suryan. Validated HPTLC Method for Simultaneous Estimation of Levocetirizine Hydrochloride and Nimesulide in Formulation. Der Pharmacia Sinica. 2011; 2(4): 117-124.
Raghad Hommoss, Hind Elzein, Samer Haidar. Determination of Levocetirizine Configurational Stability in Tablets Using Chiral Hplc Method. International Journal of Pharmacy and Pharmaceutical Sciences. 2011; 3(2): 103-107.
S.S. Merukar, P.S. Mhaskar, S.R.Bavaskar, K.B.Burade, P.N.Dhabale. Simultaneous Spectrophotometric Methods for Estimation of Levocetirizine and Pseudoephedrine in Pharmaceutical Tablet Dosage Form. J. Pharm. Sci. & Res. 2009; 1(2): 38-42.
Arindam Basu, Krishnendu Basak, Mithun Chakraborty, Inder Singh Rawat. Simultaneous RP-HPLC Estimation of Levocetirizine Hydrochloride and Montelukast Sodium in Tablet Dosage Form. International Journal of PharmTech Research. 2011; 3(1): 405-410.
Patel Nilam K. and Pancholi S. S. Spectrophotometric Determination of Montelukast Sodium and Levocetirizine Dihydrochloride in Tablet Dosage Form by AUC Curve Method. Der Pharma Chemica. 2011; 3(5): 135-140.
Chaitanya Prasad Mk, Vidyasagar G, Sambasiva Rao Krs, Madhusudhanareddy Induri and Ramanjeneyulu S. Development of Validated Liquid Chromatographic Method for Estimation of Levocetirizine from Pharmaceutical Dosage Forms. Journal of Applied Pharmaceutical Science. 2011; 1(10): 95-97.
T. Raja and A. Lakshmana Rao. Development and Validation of a Reversed Phase Hplc Method for Simultaneous Determination of Levocetirizine and Montelukast Sodium in Tablet Dosage Form. International Journal of Research in Pharmacy and Chemistry. 2012; 2(4): 1057-1063.
Sharma Smita, Sharma M. C, Kohli D.V, Sharma A.D, Development and Validation of TLC Densitometry Method for Simultaneous Quantification of Montelukast Sodium and Levocetirizine Dihydrochloride Pharmaceutical Solid Dosage Form. Scholars Research Library. Der Pharmacia Lettre. 2010: 2(1): 489-494.
Choudhari V, Kale A, Abnawe S , Kuchekar B , Gawli V ,Patil N. Simultaneous Determination of Montelukast Sodium and Levocetirizine Dihydrochloride in Pharmaceutical Preparations by Ratio Derivative Spectroscopy. IJPRIF CODEN (USA). 2010; 2(1): 4-9.
Rathore Atul S, Sathiyanarayanan L and Mahadik K.R. Development of Validated HPLC and HPTLC Methods for Simultaneous Determination of Levocetirizine Dihydrochloride and Montelukast Sodium in Bulk Drug and Pharmaceutical Dosage Form. Pharmaceutica Analytica Acta. 1(1): 1000106.
Ashokkumar S, Raja Senthil M, Perumal P. RPHPLC Method Development and Validation for Simultaneous Estimation of Montelukast Sodium and Levocetirizine Dihydrochloride. International Journal of Pharmaceutical Research. 2009; 1(4): 8-12.
Atul S. Rathore, L. Sathiyanarayanan and K.R. Mahadik. Development of Validated HPLC and HPTLC Methods for Simultaneous Determination of Levocetirizine Dihydrochloride and Montelukast Sodium in Bulk Drug and Pharmaceutical Dosage Form. Pharmaceutica Analytica Acta. 2010; 1(1): 1-6.
Mali Audumbar Digambar, Hake Gorakhnath, Patil Manojkumar, Bathe Ritesh, Tamboli Ashpak. Zero Order and Area under Curve Spectrophotometric Methods for Determination of Ampicillin Trihydrate in Pharmaceutical Formulation. GCC Journal of Science and Technology. 2015; 1(1): 6-12.
International Conference on Harmonization (ICH) of Technical Requirements for the registration of Pharmaceuticals for Human use, Validation of Analytical Procedures Methodology. ICH-Q2 (R1). Geneva, 1996, 1-8.
Copyright (c) 2015 International Journal of Advances in Scientific Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).