Visual evoked potential changes in diabetes mellitus

  • Kiran Narayan Avachar Assistant Professor, Dept of Physiology SMBT institute of medical sciences & research centre Nandi – hills, Dhamangaon, Tal - Igatpuri, dist – Nashik, Maharashtra
  • Nikhil Pandurang Sonawane Dept of obstetrics and gynaecology SMBT institute of medical sciences & research center Nandi – hills, Dhamangaon, Tal - Igatpuri, dist – Nashik, Maharashtra
  • Mundewadi Shafique Ahmed Associate Professor, Dept of Physiology Dr. V. M. Govt. Medical College, Solapur, Maharashtra
  • Shrinivas Janardan Kashalikar Professor and Head, Dept of Physiology SMBT institute of medical sciences & research centre Nandi – hills, Dhamangaon, Tal - Igatpuri, dist – Nashik, Maharashtra
Keywords: Diabetes Mellitus (DM), VEP, P100 wave, retinopathy


Background: Diabetes Mellitus (DM) a metabolic disorder is the most common cause of neuropathy. Electrophysiological studies are commonly employed to detect the neuropathy. The present study was undertaken to find out the utility of visual evoked potential (VEP) as an early indicator of central neuropathy in diabetic patients.

Materials & methods: The present study was carried out in 60 healthy subjects and 60 diagnosed DM patients of age group 20 to 40 years. Visual evoked potential (VEP) tests were recorded in sports physiology laboratory of Medical College on an outpatient basis, using RMS EMG.EP machine. It is to find out whether the VEP latencies are altered in diabetes or not.

Result: In our study there is statistically significant increase in latencies of P100 waves of both eyes in diabetic patients as compared to control subjects (p < 0.001). The N75-P100 amplitude is decreased in diabetic patients as compared to control subject but it is not statistically significant (p > 0.05).

Conclusion: The abnormalities in the VEP response occur in diabetic patients before the development of overt retinopathy. So, VEP measurements can be used for the early diagnosis of central neuropathy to offer an early opportunity for proper management.


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