A Comparative Study Between Palonosetron and Granisetron to Prevent Post Operative Nausea and Vomiting after Gynaecological Surgery

  • Rekha Solanki Assistant Professor, Department of Anaesthesia, GCRI, B J Medical College, Ahmedabad- 380016, Gujarat
  • Nita Dhiru Gosai Gujarat university B.J.Medical College,Ahmedabad,Gujarat,India .
  • Raushan Kumar Jha 2nd Year Resident, Department of Anaesthesia, GCRI, B J Medical College, Ahmedabad-380016, Gujarat,
  • Cherian Roy 1st Year Resident, Department of Anaesthesia, GCRI, B J Medical College, Ahmedabad-380016, Gujarat
  • Vibhuti Chaudhari 1st Year Resident, Department of Anaesthesia, GCRI, B J Medical College, Ahmedabad-380016, Gujarat
  • Bipin Patel Professor and HOD, Department of Anaesthesia, GCRI, B J Medical College, Ahmedabad-380016, Gujarat
Keywords: Gynaecological Surgery, Palonosetron, Granisetron, Post operative nausea and vomiting.

Abstract

Aim: Our aim of this randomized & prospective clinical study was to investigate and compare the efficacy of palonosetron HCl and granisetron HCl to prevent postoperative nausea and vomiting after gynaecological surgery.

Method: Fifty female patients of ASA grade I and II in between 18-60 years of age posted for elective gynaecological surgery were randomly divided into two groups containing 25 patients each.

Before induction of anaesthesia group P received bolus dose of palonosetron 75 mcg and group G received bolus dose of granisetron 2.5 mg intravenously slowly over a period of 30 seconds.

Result: In the postoperative period (0-3 hrs), the incidence of complete response (no postoperative nausea & vomiting, no rescue medication) was 88% with palonosetron and 76% with granisetron (p value-0.46). During 3-24 hrs postoperatively the incidence was 92% with palonosetron and 80% with granisetron (p value-0.417). During 24-48 hrs postoperatively the incidence was 92 % with palonosetron and 60 % with granisetron (p value-0.018). During 48-72 hrs incidence was statistically insignificant (p value-0.1284). Insignificant incidence of side effects between the groups was found.

Conclusion: Palonosetron is more potent and long acting than granisetron for the prevention of post operative nausea & vomiting after gynaecological surgery.

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Author Biography

Nita Dhiru Gosai, Gujarat university B.J.Medical College,Ahmedabad,Gujarat,India .

Anaesthesia Department,

Associate Professor

Published
2015-09-30
Section
Original Research Articles