Palonosetron A Promising New Prophylactic for PONV
Aim and Objective- The aim of the study was to evaluate the efficacy of palonosetron 0.075 mg for prevention of postoperative nausea and vomiting (PONV) in patients undergoing middle ear surgeries in comparison with ondansetron.
Methods- In this prospective observational study, 70 healthy patients who were undergoing elective middle ear surgeries were divided into 2 groups: Group P (palonosetron 0.075 mg i.v., n = 35) and group C (ondansetron 8 mg i.v., n = 35). The drugs were given 5 minutes before induction of anaesthesia. The incidence of nausea, vomiting, retching, severity of nausea, use of recue antiemetic and incidence of complete response were evaluated.
Results- The incidence of nausea, vomiting and severity of nausea was lower in palonosetron group as compared to ondansetron group but this difference was not statistically different. The incidence of use of rescue antiemetic (5.71% vs 23.53%) was significantly lower in palonosetron group. The incidence of complete response was higher in palonosetron group (88.87% vs 68.57%) but the difference was not statistically significant.
Conclusion- The prophylactic intravenous administration of single dose of palonosetron 0.075 mg is not more effective in controlling postoperative nausea and vomiting as compared to ondansetron 8 mg in middle ear surgery.
Honkavaara P. Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia. British Journal of Anaesthesia. 1996, 76(2), 316-318.
Singh T, Shah N, Patel C and Upadhayaya RM. A comparative study of prophylactic ondansetron versus palonosetron for post operative nausea and vomiting in middle ear surgeries. International Journal of Biomedical and Advance Research. 2014, 05(12), 619-622.
Wallenborn J, Kranke P. Review - Palonosetron Hydrochloride in the prevention and Treatment of postoperative nausea and Vomiting. Clinical Medicine Insights: Therapeutics. 2010, 2, 387-399.
Wong EH, Clark R, Leung E, et al. The interaction of RS 25259-197, a potent and selective antagonist, with 5-HT3 receptors, in vitro. British Journal of Pharmacology. 1995, 114, 851-859.
Laha B, Hazra A, Mallick S. Evaluation of antiemetic effect of intravenous palonosetron versus intravenous ondansetron in laparoscopic cholecystectomy: a randomized controlled trial. Indian Journal of Pharmacology. 2013, 45(1), 24-29.
Elahl MI, Badea M. Palonosetron in preventing postoperative nausea and vomiting in middle ear surgery: A randomized-controlled study. The Egyptian Journal of Otolaryngology. 2013, 29(3), 156-158.
Candiotti KA, Kovac AL, Melson TI, Clerici G, Gan TJ. A randomized, double-blind study to evaluate the efficacy and safety of three different doses of palonosetron versus placebo for preventing postoperative nausea and vomiting. Anesthesia & Analgesia. 2008, 107(2), 445-451.
Paventi S, Santevecchi A, Ranieri R. Efficacy of a single-dose ondansetron for preventing post-operative nausea and vomiting after laparoscopic cholecystectomy with sevoflurane and remifentanil infusion anaesthesia. European Review for Medical and Pharmacological Sciences. 2001, 5, 59-63.
Ahmed El-Hamid AM, Othman MSK, A? EE. Palonosetron versus ondansetron for prevention of postoperative nausea and vomiting during middle ear surgery: a double-blind, randomized, comparative trial. Ain-Shams J Anaesthesiol. 2014, 7(3), 309-313.
Copyright (c) 2017 International Journal of Biomedical and Advance Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (SeeThe Effect of Open Access).
- Author must Submit Copyright form After accepetance of Article.