A comparison of oral clonidine with oral midazolam for premedication in paediatric anaesthesia

  • Sheetal Dalal Associate Professor, Department of Anaesthesiology, Indira Gandhi Government Medical College and Hospital, Nagpur, Maharashtra
  • Chetan Ronghe Senior Resident, Department of Anaesthesiology, Indira Gandhi Government Medical College and Hospital, Nagpur, Maharashtra
Keywords: coratina olive, IBA, Cuttings


Background: Midazolam is currently the most commonly used premedicant, but newer drugs such as the α2-agonists have emerged as alternatives for premedication in children. Hence the present study was undertaken to compare the clinical effects of oral clonidine and oral midazolam for premedication in paediatric anaesthesia. Method: In a prospective, observational study, 60 children of age range from 2-10 years, ASA grade I and II were randomly assigned in two groups to receive either oral clonidine 4mcg/kg (Group C) or oral midazolam 0.5mg/kg (Group M) prior to induction of anaesthesia. Drug acceptance, preoperative sedation, anxiolysis, parenteral separation, venepuncture, quality of mask acceptance and induction, perioperative haemodynamic stability, postoperative sedation and behavior were noted. Results: Both the drugs were palatable with honey out of 30 patients in each group, 9(30%) patients in group-C and 8(26.66%) patients in group-M taste as indifferent but palatable. Onset of sedation was significantly faster after premedication with midazolam (31.00 ± 8.03 min) than with clonidine (40 ± 7.88 min). At 30 to 50 minutes, anxiolysis was better in group M than group C while the quality of parental separation was better in group-C than group-M. At the time of venous cannulation children were more sedated in group C than in group M. Oral clonidine was better premedicant than oral midazolam in paediatric patients in terms of mask acceptance, quality of induction, hemodynamic stability and post operative behaviour. Conclusion: From the above results, current study recommends use of oral clonidine 4mcg/kg as a novel premedicant in paediatric anaesthesia.


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How to Cite
Dalal, S., & Ronghe, C. (2019). A comparison of oral clonidine with oral midazolam for premedication in paediatric anaesthesia. International Journal of Biomedical and Advance Research, 10(01), e5028. https://doi.org/10.7439/ijbar.v10i01.5028
Original Research Articles