Beta Thalassemia and its variant: A Clinicopathological correlation of 100 cases in Bihar, India

Status of beta thalassemia in Bihar

  • Anil Kumar Thakur
  • Subhash Chandra Jha Assistant professor, Department of Pathology, Government, Medical College, Bettiah, Pin code: 845438, Email ID: jhapatho25@gmail.com Mobile
  • Prasanna Kumar Mishra Assistant Professor, Department of Pathology, Anugrah Narayan Magadh Medical College, Gaya, Bihar
  • Dilip Kumar Pandey
Keywords: Suicide, suicidal behaviors, biopsychosocial, public health

Abstract

Background: Thalassemia is a heterogeneous group of genetical disorders of hemoglobin (Hb) characterized by reduced or absent production of globin chains. It is the major health problemin the Indian subcontinent as the prevalence rate of beta thalassemia mutations is as high as 17% in some populations. The overall prevalence of β-thalassemia trait is 2.78% and varies from 1.48 to 3.64% in different states, while the prevalence of β-thalassemia trait in 59 ethnic groups varies from 0 to 9.3% Materials and Methods: This study was conducted in the department of pathology of a tertiary care teaching medical colleges and hematology centre in Bihar, India from August 2017 to December 2018. Patients who came with weakness, history of multiple blood transfusions and abnormal hemograms suggestive ofanemia with microcytic hypochromic bloodpictures, and also those patients who had a positive family history of thalassemia were included in the study. Result: During the study period of 1 year and 3 months, a total of 100 cases were studied. The age of the patients ranged between 4 months (Female), beta thalassemia majorand 55(Male) years, beta thalassemia intermedia. Male female ration was 3.76. The most common thalassemia in this study was Beta thalassemia major (52%) and second was Beta E thalassemia major (31%) Conclusion: study of incidence and prevalence of common Beta Thalassemias in a particular region helps to formulate appropriate preventive and therapeutic strategies.

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Author Biographies

Anil Kumar Thakur

Assistant Professor, department of Pathology, Anugrah Narayan Medical College, Gaya, Bihar

Subhash Chandra Jha, Assistant professor, Department of Pathology, Government, Medical College, Bettiah, Pin code: 845438, Email ID: jhapatho25@gmail.com Mobile
Assistant professor, Department of Pathology, Government, Medical College, Bettiah,   Pin code: 845438, Email ID: jhapatho25@gmail.com Mobile
Dilip Kumar Pandey

Assistant, Professor , department of Pathology,Anugrah Narayan Medical College, Gaya, Bihar

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Published
2019-02-14
How to Cite
Thakur, A., Jha, S., Mishra, P., & Pandey, D. (2019). Beta Thalassemia and its variant: A Clinicopathological correlation of 100 cases in Bihar, India. International Journal of Biomedical and Advance Research, 10(2), e5085. https://doi.org/10.7439/ijbar.v10i2.5085
Section
Original Research Articles