Study of lipid profile in subjects with vitamin D3 deficiency
Correlation of lipid profile and vitamin D3.
Introduction: Vitamin D3 deficiency is more prevalent throughout India. Some recent studies have suggested possible associations between lipid profile and deficiency of vitamin D3.
Aim and Objectives: To investigate the association between vitamin D3 and lipid profile in Indian subjects.
Study design: This is a cross-sectional study.
Material and Method: Two hundred individuals were considered for the study, from whom 100 individuals with vitamin D3 deficiency were included in the case group and control groups contain 100 normal healthy individuals. Serum concentration of vitamin D3 and lipid profile were measured by fully automated biochemistry analyzers.
Results: The mean serum concentrations of total cholesterol, LDL, triglyceride, VLDL, TC/HDL ratio, LDL/HDL ratio in the case group (190.92 ± 27.64 mg/dl, 117.01 ± 24.99 mg/dl, 116.35 ± 29.76 mg/dl, 25.71 ± 10.54 mg/dl, 4.21 ± 1.21, 2.62 ± 0.96 respectively) were statistically significantly higher than the control group (172.91 ± 21.40 mg/dl, 97.38 ± 17.96 mg/dl, 102.75 ± 29.89 mg/dl, 20.55 ± 5.98 mg/dl, 3.20 ± 0.50, 1.81 ± 0.42 respectively) with P value of <0.01 and the mean serum HDL concentration in the case group (48.18 ± 12.52 mg/dl) was statistically significantly lower than the control group (54.95 ± 8.73 mg/dl) with P value of <0.0001.
Conclusion: Serum vitamin D3 concentrations showed an inverse correlation with s. cholesterol, LDL, VLDL, triglyceride (atherogenic lipids) and a positive correlation with HDL (atheroprotective).
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