Synthesis and characterization of some novel indole based 1,3,4-oxadiazoles with antimicrobial activity
AbstractA novel series of various 1-[5-(1H-indol-3-ylmethoxymethyl)-2-phenyl-[1,3,4]oxadiazol-3-yl]-ethanone and its derivatives (5a-f) were synthesized from (1H-indol-3-ylmethoxy)-acetic acid-benzylidene-hydrazide and its derivatives (4a-f) by using (1H-indol-3-yl)-methanol (1) as raw material and including (1H-indol-3-ylmethoxy)-acetic acid ethyl ester (2) and (1H-indol-3-ylmethoxy)-acetic acid hydrazide (3) as intermediates. The chemical structures of all these compounds have been entrenched by IR, 1H & 13C-NMR, mass spectral data and elemental analysis. The newly synthesized compounds have been used to find their potential in order to achieve the antibacterial and antifungal activities.
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