Estimation of plasma glutathione levels in NIDDM patients with and without cardiovascular disease

  • Axita C Vani SDM Medical College, Sattur, Dharwad
  • Hemanthkumar R G Department of Forensic Medicine & Toxicology, SDM College of Medical Sciences, Sattur, Dharwad, Karnataka
Keywords: NIDDM, cardiovascular diseases, GSH(reduced Glutathione), HPLC


Diabetes mellitus is a group of metabolic derangements characterised by hyperglycemia resulting from defective insulin secretion or action or both. Persistent hyperglycemia generates reactive oxygen species causing oxidative damage to cells and various biomolecules. In this study the levels of reduced glutathione antioxidant were estimated in NIDDM patients with cardiovascular disease (n=50) by HPLC method and compared to healthy controls (n=50). The results indicated that plasma glutathione levels are significantly decreased showing that antioxidant defence is lowered in diabetic patients with cardiovascular complications.


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Author Biography

Axita C Vani, SDM Medical College, Sattur, Dharwad
Assistant Professor, dept of Biochemistry
Original Research Articles