Evaluation of metabolic syndrome in young depressive psychiatric outpatients
Objectives: Metabolic syndrome is a highly prevalent disorder among the general population. Studies show an even higher prevalence among psychiatric patients. Cardiovascular disease is one of the most prevalent factors responsible for excess mortality in depression. Metabolic syndrome is associated with the development of coronary heart disease and diabetes mellitus. The objective of this study was to evaluate the prevalence of Metabolic syndrome in young depression psychiatric outpatients.
Methods: 30 depressive outpatients of both sex in the age group of 20-40yrs and 28 heathy, age and sex matched controls were selected and evaluated according to the National Cholesterol Education Program criteria for metabolic syndrome, with a modification of the criteria for blood pressure and fasting glucose.
Results: Except fasting blood sugar (p = 0.415) and systolic blood pressure (p = 0.132), all other parameters like, total cholesterol (p = 0.009), HDL (p = 0.0001), LDL (p = 0.001) VLDL (p = 0.002) cholesterols, triacylglycerol (p = 0.002), waist circumference (p = 0.003) and diastolic blood pressure (p = 0.002) measured in depressive patients were found to be increased and statistically highly significant than controls.
Conclusions: This study shows an increased prevalence of Metabolic syndrome in depression psychiatric outpatients than controls associated with the development of coronary heart disease and diabetes mellitus. The aim of this study was to evaluate the prevalence of Metabolic syndrome in depression psychiatric outpatients.
Reaven GM. Syndrome X: 6 years later. J Int Med. 1994; 236(Suppl 736):13-22.
Grundy SM, Brewer HB Jr, Cleeman JI, Smith SC Jr, Lenfant C; American Heart Association; National Heart, Lung, and Blood Institute. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Instittute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation. 2004; 109(3):433-8.
Teixeira PJ, Rocha FL. Efeitos adversos metablicos de antipsicticos atpicos e estabilizadores de humor.Rev Psiquiatr RS. 2006; 28(2):186-96.
Wirshing D. Schizophrenia and obesity: impact of antipsychotic medications. J Clin Psychiatry. 2004; 65(Suppl 18):13-26.
Sena EP, Sampaio AS, Quarantini LC, de Oliveira IR. Diabetes mellitus e antipsicticos atpicos. Rev Bras Psiquiatr. 2003; 25(4):253-7.
American Diabetes Association; American Psychiatric Association; American Association of Clinical Endocrinologists; North American Association for the Study of Obesity. Consensus Development Conference on Antipsychotic Drugs and Obesity and Diabetes. J Clin Psychiatry. 2004; 65(2):267-72.
Organizao Mundial de Sade. Classificao de transtornos mentaise de comportamento da CID-10. Porto Alegre: Artes Mdicas; 1993.
Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA. 2001; 285(19):2486-97.
International Diabetes Federation The IDF worldwide definition of the metabolic syndrome. [cited: 2006 Jun 26] Available from: URL: http://www.idf.org/home/index.cfm?unode=1120071EAACE- 41D2-9FA0-BAB6E25BA072.
Schettler, G. and Nussel, E., Arb. Med. Soz. Med. Prav. Med. 10, 25 (1975).
Richomond, W., Clin. Chem. 19, 1350 (1974)
Roschlau, P. et al., J. Clin. Chem. Clin. Biochem. 12, 403 (1974)
Trinder, P., Ann. Clin. Biochem. 6, 24 (1969)
Grove T H. Effects reagent pH on Determination of HDL Cholesterol By precipitation with Sodium Phosphotungstate-Magnesium. Clin Chem 25:560, 1979.
Naito H K HDL Cholesterol. Kaplan A et al., Clin Chem. The C. V. Msoby Co. St Louis, Toronto, Princeton 1984; 1207-1213 and 437.
Tietz N W et al. Clinical Guide to Laboratory Tests, 3rd ed AACD 1995.
Barham, D., Trinder, P., Analyst 97 (1972)
Teuscher, A., Richterich P., Schweiz Med. Wschr. 101, 345 and 390 (1971)
Blumenthal JA, Williams RS, Wallace AG, Williams RB, Needles TL. Physiological and psychological variables predict compliance to prescribed exercise therapy in patients recovering from myocardial infraction. Psychosom Med 1982; 44:519-27.
Finnegan DL, Suler JR. Psychological factors associated with maintenance of improved health behaviors in post coronary patients. J Psychol 1985; 119:87-94.
Guiry E, Conory RM, Hickdy N, Mulcahy Re. Psychological response to an acute coronary event and its effect on subsequent rehabilitation and lifestyle change. Clin Cardiol 1987; 10: 256-60.
Everson-Rose SA, Meyer PM, Powell LH, et al. Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care 2004; 27:2856-62.
Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation 1999; 2192-2217.
Wang J, Ruotsalainen S, Moilanen L, Lepist P, Laakso M & Kuusisto J: The metabolic syndrome predicts cardiovascular mortality: a 13-year follow-up study in elderly non-diabetic Finns. Eur Heart J 2007; 28:857-64.
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