Retracted: Saliva: A systematic review on its diagnostic utility

  • Neeharika Mortha Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
  • Divya Uppala Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
  • Nandita Kothia Department of Public Health Dentistry, SIBAR Institute of Dental Sciences, Takkelapadu, Guntur-522509
  • Sumit Majumdar Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
  • Kodati Sravya Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
Keywords: Oral, Analytes, Biomarkers, Database

Abstract

Introduction: A paradigm shift in recent years has led to the consideration of the oral cavity (and, thus, oral disease) not in isolation but as a component integrated with systemic physiology, important in maintaining systemic health and reflective of systemic disease. Saliva has been studied extensively as a potential diagnostic tool over the last decade due to its ease and non-invasive accessibility along with its abundance of biomarkers.

Aim & Objective: This is a systematic review of the studies published in past 15 years in electronic databases regarding the utility of saliva as a diagnostic tool

Materials & Methods: Data collection from electronic databases, followed by data extraction and management.

Results & Conclusion: Of 85 studies considered among 510, represent the evolution of saliva in screening neoplasm, with 34 different analytes detected in this population followed by 22 in metablic disorders and the least being in systemic disorders. Most abundantly applied technique being ELISA, common analyte being Immunoglobulins. The application of high throughput proteomic techniques in various studies in the past decade has led to the discovery of new biomarkers.

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Author Biographies

Neeharika Mortha, Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
Post Graduate student, Department of Oral Pathology
Divya Uppala, Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
READER, GITAM DENTAL COLLEGE & HOSPITAL
Nandita Kothia, Department of Public Health Dentistry, SIBAR Institute of Dental Sciences, Takkelapadu, Guntur-522509
Assistant Professor,Department of Public Health Dentistry
Sumit Majumdar, Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
professor & Head of the Department
Kodati Sravya, Department of Oral & MaxilloFacial Pathology, GITAM Dental College & Hospital, Visakhapatnam, 530045
Post Graduate student, Department of Oral Pathology
Published
2018-01-30
Section
Original Research Articles