Evaluation of analgesic efficacy of two different doses of Pregabalin for attenuation of post-operative pain in laparoscopic cholecystectomy
Background: Literature established the role of pregabalin in the pain management. However, there are limited studies in attenuating postoperative pain after laparoscopic cholecystectomy (LAC). So, we evaluate the analgesic effect of two different doses of Pregabalin for attenuation of post-operative pain in laparoscopic cholecystectomy
Methodology: In this randomized prospective study, 120 patients were allocated into three groups of 40 each. Group A, B and C received Tab Vitamin, Tab Pregabalin 75 mg and 150 mg respectively 1 hour before the expected time of anesthesia. Postoperative efficacy among these three groups was compared with respect to increase in duration of analgesia, reduction in postoperative pain scores, total postoperative requirements of analgesics and side effects.
Results: Pregabalin does not reduce pain intensity during 24-hr following LAC as compared to placebo. No difference in need for rescue analgesic, time for need of first rescue analgesic dose and amount of fentanyl and Diclofenac requirement in three groups was observed. No other side effect was reported in any of the groups at any post-operative interval.
Conclusion: The findings in present study suggested that Pregabalin does not provide a better preemptive pain control than placebo in cases undergoing LAC.
2. Shoar S, Esmaeili S, Safari S. Pain Management after Surgery: A Brief Review. Anesth Pain. 2012; 1(3):184-6.
3. Chizh BA, Gohring M, Troster A, Quartey GK, Schmelz M, Koppert W. Eﬀects of oral pregabalin and aprepitant on pain and central
sensitization in the electrical hyperalgesia model in human volunteers. Br J Anaesth. 2007; 98(2):246-54.
4. Shneker BF, McAuley JW. Pregabalin: a new neuromodulator with broad therapeutic indications. Ann Pharmacother. 2005; 39(12):2029-37.
5. Paech MJ, Goy R, Chua S, Scott K, Christmas T, Doherty DA. A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery. Anesth Analg. 2007; 105(5):1449-53.
6. Jokela R, Ahonen J, Tallgren M, Haanpää M, Korttila K. Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br J Anaesth. 2008; 10(6): 834-40.
7. Jokela R, Ahonen J, Tallgren M, Haanpää M, Korttila K. A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy. Pain. 2008; 134(1-2):106-12.
8. Chang SH, Lee HW, Kim HK, Kim SH, Kim DK. An evaluation of perioperative pregabalin for prevention and attenuation of postoperative shoulder pain after laparoscopic cholecystectomy. Anesth Analg. 2009; 109(4):1284-6.
9. Zhang J, Ho K-Y, Wang Y. Efficacy of pregabalin in acute postoperative pain: a meta-analysis. Br J Anaesth 2011; 106(4): 454-62.
Copyright (c) 2019 International Journal of Biomedical Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.