Evaluation of analgesic efficacy of two different doses of Pregabalin for attenuation of post-operative pain in laparoscopic cholecystectomy

  • Sneha Singh Senior Resident, Department of Neuroanesthesiology, AIIMS, New Delhi
  • Shalendra Singh Neuroanaesthesiologist & Critical care specialist
  • Amit Sharma Senior Advisor (Anaesthesiology), Base Hospital Delhi Cantt, New Delhi
  • Priya Taank Department of Ophthalmology, CH (SC), PUNE
  • Deepak Dwivedi

Abstract

Background : Literature established the role of pregabalin in the pain management. However, there are limited studies in attenuating postoperative pain after laparoscopic cholecystectomy (LAC). So, we evaluate the analgesic effect of two different doses of Pregabalin for attenuation of post-operative pain in laparoscopic cholecystectomy Methodology : In this randomized prospective study, 120 patients were allocated into three groups of 40 each. Group A, B and C received Tab Vitamin, Tab Pregabalin 75 mg and 150 mg respectively 1 hour before the expected time of anesthesia. Postoperative efficacy among these three groups was compared with respect to increase in duration of analgesia, reduction in postoperative pain scores, total postoperative requirements of analgesics and side effects. Results: Pregabalin does not reduce pain intensity during 24-hr following LAC as compared to placebo. No difference in need for rescue analgesic, time for need of first rescue analgesic dose and amount of fentanyl and Diclofenac requirement in three groups was observed. No other side effect was reported in any of the groups at any post-operative interval. Conclusion: The findings in present study suggested that Pregabalin does not provide a better preemptive pain control than placebo in cases undergoing LAC.

Downloads

Download data is not yet available.

References

1. Lau H, Brooks DC. Predictive factors for unanticipated admissions after ambulatory laparoscopic Cholecystectomy. Arch Surg. 2001 Oct; 136(10):1150-3.
2. Shoar S, Esmaeili S, Safari S. Pain Management after Surgery: A Brief Review. Anesth Pain. 2012; 1(3):184-6.
3. Chizh BA, Gohring M, Troster A, Quartey GK, Schmelz M, Koppert W. Effects of oral pregabalin and aprepitant on pain and central
sensitization in the electrical hyperalgesia model in human volunteers. Br J Anaesth. 2007; 98(2):246-54.
4. Shneker BF, McAuley JW. Pregabalin: a new neuromodulator with broad therapeutic indications. Ann Pharmacother. 2005; 39(12):2029-37.
5. Paech MJ, Goy R, Chua S, Scott K, Christmas T, Doherty DA. A randomized, placebo-controlled trial of preoperative oral pregabalin for postoperative pain relief after minor gynecological surgery. Anesth Analg. 2007; 105(5):1449-53.
6. Jokela R, Ahonen J, Tallgren M, Haanpää M, Korttila K. Premedication with pregabalin 75 or 150 mg with ibuprofen to control pain after day-case gynaecological laparoscopic surgery. Br J Anaesth. 2008; 10(6): 834-40.
7. Jokela R, Ahonen J, Tallgren M, Haanpää M, Korttila K. A randomized controlled trial of perioperative administration of pregabalin for pain after laparoscopic hysterectomy. Pain. 2008; 134(1-2):106-12.
8. Chang SH, Lee HW, Kim HK, Kim SH, Kim DK. An evaluation of perioperative pregabalin for prevention and attenuation of postoperative shoulder pain after laparoscopic cholecystectomy. Anesth Analg. 2009; 109(4):1284-6.
9. Zhang J, Ho K-Y, Wang Y. Efficacy of pregabalin in acute postoperative pain: a meta-analysis. Br J Anaesth 2011; 106(4): 454-62.
Abstract : 0 | PDF : 0
Published
2019-01-09
How to Cite
1.
Singh S, Singh S, Sharma A, Taank P, Dwivedi D. Evaluation of analgesic efficacy of two different doses of Pregabalin for attenuation of post-operative pain in laparoscopic cholecystectomy. IJBR [Internet]. 9Jan.2019 [cited 19Apr.2019];10(1):e4991. Available from: https://ssjournals.com/index.php/ijbr/article/view/4991
Section
Original Research Articles