Plant extracts of suruhan (Peperomia pellucida L. Kunth) ameliorate infertility of male mice with alloxan-induced hyperglycemia

Abstract

Introduction and Aims : This study was conducted to determine the effect of plant extracts of suruhan (Peperomia pellucida L. Kunth) on the blood glucose level and sperm parameters in male mice with alloxan-induced hyperglycemia. Materials and methods: By using a completely randomized design, 25 male albino mice were grouped into five with five replications each. Group 1 treated with alloxan at the dose of 150 mg/kg bw (as negative control). Group 2 was given alloxan and glibenclamide of 0.65 mg/kg bw (as positive control). Group 3, 4 and 5 were treated with alloxan and plant extracts at the dose of 56, 112 and 168 mg/kg bw respectively. Injection of alloxan was done 3 times in 6 days and the plant extract was given every day for 35 days. Results: Results showed plant extracts of suruhan significantly lowering blood glucose levels, ameliorate sperms count, viability, motility, and morphology. Conclusion: It suggests that plant extract of Peperomia pellucida is potential to be used as antidiabetic and male fertility recovery agents