Effect of Palonosetron monotherapy versus Palonosetron with Dexamethasone combination therapy for prevention of post operative nausea vomiting in children undergoing strabismus surgery

  • Varun Bajaj Senior Resident, Department of anaesthesia, VMMC & Safdarjung Hospital, New Delhi
  • Shalendra Singh Neuroanaesthesiologist and Critical Care Specialist, AFMC, Pune
  • Ritesh Sharma Assistant Professor, Department of Anaesthesia, Command Hospital Kolkota, West Bengal
  • Priya Taank Department of Ophthalmology, CH (SC), Pune http://orcid.org/0000-0002-4167-5376
  • Deepak Dwivedi Department of Anaesthesiology, CH (SC), Pune
Keywords: anaesthesia, brain abscess, tetralogy of fallot, surgery


Background: Postoperative nausea and vomiting (PONV) is the most distressing symptom reported in 40 88% of patients subsequent to strabismus surgery. Newer antiemetic 5-HT3 receptor antagonist drugs palonosetron and its combination with dexamethasone for prevention PONV in chemotherapy patients having promising results, but has not been studied in children undergoing strabismus surgery.

Methodology: 120 patients were registered in this prospective, randomized double blind study. Group A received palonosetron 1.5 mcgkg-1 and Group B received an additional dose of Inj dexamethasone 0.25 mgkg-1 prior to anaesthesia. Post operative data of PONV and postoperative vomiting (POV) was recorded at pre defined intervals in different age groups.

Results: There is no difference of POV in both groups at different age groups. The incidence of post operative nausea in Group A was 44% and Group B was 11% (p=0.02).Considering the incidence of PONV in all age groups, our results showed that the overall incidence of PONV in Group A was found to be more than that with Group B (p 0.05). Also in age group 3 year to 9 year, the incidence of PONV was higher in Group A than Group B (p =0.01).The incidence of PONV was found to be 17% (6 out of 36), 21% (14 out of 68) and 6% (1 out of 16) when one, two and three extra ocular muscles were operated respectively(p=0.39).

Conclusion: Palonosetron with dexamethasone combination therapy is recommended to be used in children age > 3years undergoing strabismus surgery.


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How to Cite
Bajaj V, Singh S, Sharma R, Taank P, Dwivedi D. Effect of Palonosetron monotherapy versus Palonosetron with Dexamethasone combination therapy for prevention of post operative nausea vomiting in children undergoing strabismus surgery. IJBR [Internet]. 14Feb.2019 [cited 24Mar.2019];10(2):e5080. Available from: https://ssjournals.com/index.php/ijbr/article/view/5080
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