FT-IR Spectroscopic Assay Method for Eslicarbazepine Acetate in Bulk and Tablet Formulations

  • Ravi Prasad Indian Institute of Chemical Technology, Hyderabad
  • Bhuvaneswari Kotamarthi Indian Institute of Chemical Technology, Hyderabad
  • Rajani Kompally Indian Institute of Chemical Technology, Hyderabad
  • Anu Radha Indian Institute of Chemical Technology, Hyderabad
Keywords: FT-IR, Eslicarbazepine Acetate, Absorbance, Tablet formulation.

Abstract

A simple, precise and rapid FT-IR spectroscopic method has been developed for the quantification of Eslicarbazepine acetate (ECA) in bulk and tablet formulations. The method involves the measurement of absorbance of carbonyl (C=O) peak at 1726 cm-1 and evaluation of unknown drug component from the measured absorbance values using standard calibration plot. The method was validated as per ICH guidelines and successfully applied for the estimation of ECA in pharmaceuticals in tablet form.

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Author Biographies

Ravi Prasad, Indian Institute of Chemical Technology, Hyderabad

Analytical Chemistry Division

Bhuvaneswari Kotamarthi, Indian Institute of Chemical Technology, Hyderabad

Analytical Chemistry Division

Rajani Kompally, Indian Institute of Chemical Technology, Hyderabad
Analytical Chemistry Division
Anu Radha, Indian Institute of Chemical Technology, Hyderabad
Analytical Chemistry Division
Published
2015-07-30
Section
Research Articles