Evaluation of Anticancer, Antioxidant and Possible Anti-microbial Properties of extracts of Momordica diocia roots

  • Vijay Kumar G. Department of Pharmaceutical Chemistry, Jangaon institute of Pharmaceutical Sciences, Warangal, Telangana, India-506167
  • A. Rajasekhar Reddy Department of Pharmacy, K L University, Vaddeswaram, Guntur, A. P.522502
  • Vijaya Kumar B. Department of Pharmaceutical Chemistry, Jangaon institute of Pharmaceutical Sciences, Warangal, Telangana 506167
Keywords: Momordicadioica, XTT, anticancer, antibacterial and antioxidant


Since many years, plants were known to possess anticancer activities against different cancer cell lines. In this paper, we report a study based on anticancer,anti-bacterial and antioxidant properties plants Momordicadioica. The roots of plant material were collected, shade dried and extracted with methanol using soxhlet extraction procedure. Anticancer activities were assayed with standard XTT colorimetric procedure against MCF-7 and Hep-G2 cell lines. From the analysis, it was found that Momordicadioicashowed good cytotoxic activity on MCF-7 cell line at tested dose. Further work is in progress to evaluate the chemical constituents present in these plants


Download data is not yet available.


Dubey NK, Kumar R, Tirupathi P. Global promotion of herbal medicine: India opportunity. Curr Sci 2004; 86(1): 37-41.

Sofowora A. Medicinal plants and traditional medicine. In: Africa. New York: John Willey Sons Ltd.; 1982, p. 6

Maharudra S Rakh, Amol N Khedkar, Nilesh N Aghav, Sanjay R Chaudhari, Antiallergic and analgesic activity of MomordicadioicaRoxb. Wild fruit seed, Asian Pacific Journal of Tropical Biomedicine, 2012, S192-S196

P Srinivas, S Ram Reddy, Screening for antibacterial principle and activity of Aervajavanica (Burm f) Juss. ex Schult. Asian Pacific Journal of Tropical Biomedicine, 2012, S838-S845

Namdeo A. Plant cell elicitation for production of secondary metabolites: A review. Pharmacog Rev 2007; 1: 69-79.


Species in GRIN for genus Momordica; https://npgsweb.ars-grin.gov/gringlobal/taxonomylist.aspx?category=species&type=genus&value=a%20genus&id=7719

The International Plant Names Index; http://www.ipni.org/ipni/ advPlantNameSearch.do?find_family=&find_genus=Momordica&find_species=&find_infrafamily=&find_infragenus=&find_infraspecies=&find_authorAbbrev=&find_includePublicationAuthors=on&find_includePublicationAuthors=off&find_includeBasionymAuthors=on&find_includeBasionymAuthors=off&find_publicationTitle=&find_isAPNIRecord=on&find_isAPNIRecord=false&find_isGCIRecord=on&find_isGCIRecord=false&find_isIKRecord=on&find_isIKRecord=false&find_rankToReturn=spec&output_format=normal&find_sortByFamily=on&find_sortByFamily=off&query_type=by_query&back_page=plantsearch

Maharudra S Rakh, Amol N Khedkar, Nilesh N Aghav, Sanjay R Chaudhari, Antiallergic and analgesic activity of MomordicadioicaRoxb. Willd fruit seed, Asian Pacific Journal of Tropical Biomedicine,2012, S192-S196.

C. S. Shreedhara, V. P. Vaidya, Screening of Momordicadioica for hepatoprotective, antioxidant, and anti-in?ammatory activities, Natural Product Sciences, vol. 12, no. 3, pp. 157161, 2006.

C. S. Shreedhara, H. N. Aswatha Ram, S. B. Zanwar, and F. P. Gajera, In vitro antioxidant potential of ethanolic extract of MomordicadioicaRoxb (Cucurbitaceae), Pharmacologyonline, vol. 3, pp. 622633, 2011.

B. Shrinivas, S. Anil, M. Parera, and M. Saxena, Evaluation of antimicrobial and antioxidant properties of MomordicadioicaRoxb.(ExWilld), Journal of Pharmaceutical Research,vol.2,no.6, pp. 10751078, 2009.

A.Jain,M.Soni,L.Debetal,Antioxidant and hepatoprotective activity of ethanolic and aqueous extracts of MomordicadioicaRoxb. leaves, Journal of Ethnopharmacology, vol. 115, no. 1, pp.6166, 2008.

K. Ilango, G. Maharajan, and S. Narasimhan, Analgesic andAnti-in?ammatory Activities of Momordicadioica Fruit Pulp,Natural Product Sciences, vol. 9, no. 4, pp. 210212, 2003.

V. P. Vaidya, C. S. Shreedhara, Medicinal values of theroot of Momordicadioica (Cucurbitaceae), in Proceedings ofthe 1st National Interactive Meet on Medicinal & Aromatic Plants(CIMAP 03), pp. 278281, Lucknow, India, 2003.

M. S. Rakh and S. R. Chaudhari, Evaluation of analgesic activity of Momordicadioicaroxb. Wild fruit pulp, InternationalJournal of Pharmaceutical Science and Research, vol. 1, no. 9, pp.5356, 2010.

A. Jain and A. K. Singhai, E?ect of MomordicadioicaRoxbon gentamicin model of acute renal failure, Natural ProductResearch, vol. 24, no. 15, pp. 13791389, 2010.

A. Jain and A. K. Singhai, Nephroprotective activity ofMomordicadioicaRoxb. in cisplatin-induced nephrotoxicity,Natural Product Research, vol. 24, no. 9, pp. 846854, 2010.

R. Gupta, P. Katariya, M. Mathur et al., Antidiabetic andrenoprotective activity of Momordicadioica in diabetic rats,DiabetologiaCroatica, vol. 40, no. 3, pp. 8188, 2011.

M. S. Rakh and S. R. Chaudhari, Evaluation of CNS depressantactivity of MomordicadioicaRoxbwild fruit pulp, International Journal of Pharmacy and Pharmaceutical Sciences, vol. 2,supplement 4, pp. 124126, 2010.

M. S. Rakh, A. N. Khedkar, N. N. Aghav, and S. R. Chaudhari,Antiallergic and analgesic activity of MomordicadioicaRoxb.Wild fruit seed, Asian Pacific Journal of Tropical Biomedicine,vol. 2, supplement 1, pp. S192S196, 2012.

P. P. Gupta, R. C. Srimal, and J. S. Tandon, Antiallergic activityof some traditional Indian medicinal plants, InternationalJournal of Pharmacognosy, vol. 31, no. 1, pp. 1518, 1993.

B. M. R. Fernandopulle, W. D. Ratnasooriya, and E. H.Karunanayake, Evaluation of two cucurbits (Genus:Momordica) for gastroprotective and ulcer healing activity inrats, Medical Science Research, vol. 24, no. 2, pp. 8588, 1996.

M. Vijayakumar, M. B. Eswaran, S. K. Ojha, C. V. Rao, andA. K. S. Rawat, Antiulcer activity of hydroalchol extract ofMomordicadioicaroxb. fruit, Indian Journal of PharmaceuticalSciences, vol. 73, no. 5, pp. 572577, 2011.

J. A. Arekar, A. R. Arekar, and G. T. Paratkar, Screeningof antibacterial activity of ?avonoid fractions of Momordicadioica, Roxb., Global Journal of Bio-Science and Biotechnology,vol. 2, no. 2, pp. 235237, 2013.

R. Singh, S. Hussain, R. Verma, and P. Sharma, Antimycobacterial screening of fIve Indian medicinal plants andpartial purification of active extracts of Cassia sophera andUrticadioica, Asian Pacific Journal of Tropical Medicine, vol.6, no. 5, pp. 366371, 2013.

B. M. R. Fernandopulle, E. H. Karunanayake, and W. D.Ratnasooriya, Oral hypoglycemic e?ects of Momordicadioicain the rat, Medical Science Research, vol. 22, no. 2, pp. 137139,1994.

G. T. Reddy, B. R. Kumar, and G. K. Mohan, Antihyperglycemicactivity of Momordicadioicafruits in alloxan-induced diabeticrats, Nigerian Journal of Natural Products and Medicine, vol. 9,pp. 3334, 2005.

R. Singh, A. Seherawat, and P. Sharma, Hypoglycemic, antidiabetic and toxicological evaluation of Momordicadioica fruitextracts in alloxan induced diabetic rats, Journal of Pharmacology and Toxicology, vol. 6, no. 5, pp. 454467, 2011.

R. Sharma and V. Arya, A review on fruits having anti-diabeticpotential, Journal of Chemical and Pharmaceutical Research,vol. 3, no. 2, pp. 204212, 2011.

Martin Muthee Gakuubi,1,2 John M. Wagacha,1 Saifuddin F. Dossaji,1 and Wycliffe Wanzala3, Chemical Composition and Antibacterial Activity of Essential Oils of Tagetesminuta(Asteraceae) against Selected Plant Pathogenic Bacteria, International Journal of Microbiology, Volume 2016 (2016), Article ID 7352509

Ebrahimzadeh MA1, Bahramian F. Antioxidant activity of Crataeguspentaegynasubsp. elburensis fruits extracts used in traditional medicine in Iran. Pak J Biol Sci. 2009 Mar 1;12(5):413-9.

Mahmoudi, M, Ebrahimzadeh, M. A, Ansaroudi, F, Nabavi, S. Fand Nabavi, S. MAntidepressant and antioxidant activities of Artemisiaabsinthium L. at flowering stage, African Journal of Biotechnology Vol. 8 (24), pp. 7170-7175, 15 December, 2009.

Munari CC, de Oliveira PF, Campos JC, Martins Sde P, Da Costa JC, Bastos JK, Tavares DC, Antiproliferative activity of Solanum lycocarpumalkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines. J Nat Med. 2014 Jan;68(1):236-41.

Sunil Sagar, Luke Esau, BasemMoosa, Niveen M. Khasha, Vladimir B. Bajic, and Mandeep Kaur, Cytotoxicity and Apoptosis Induced by a Plumbagin Derivative in Estrogen Positive MCF-7 Breast Cancer Cells, Anticancer Agents Med Chem. 2014 Jan; 14(1): 170180.

P. Senthilraja, K. Kathiresan, In vitro cytotoxicity MTT assay in Vero, HepG2 and MCF -7 cell lines study of Marine Yeast, Journal of Applied Pharmaceutical Science Vol. 5 (03), pp. 080-084, March, 2015.

Anderson Junger Teodoro, Felipe Leite Oliveira, Nathalia Balthazar Martins, Guilherme de Azevedo Maia, Renata Brum Martucci and Radovan Borojevic, Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines, Cancer Cell International, 2012, 12:36.

N. P. C. Fernandes, C. V. Lagishetty, V. S. Panda, and S. R. Naik, An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordicacharantia fruit extract, BMC Complementary and Alternative Medicine, vol. 7, Article ID 29, 2007.

Singh RK, Dhiman RC, Mittal PK, Mosquito larvicidal properties of Momordicacharantia Linn (family: Cucurbitaceae).J Vector Borne Dis. 2006 Jun;43(2):88-91.

D. Singh, V. Bahadur, D. B. Singh, and G. Ghosh, Spine gourd (Momordicadioica): an underutilized vegetable with high nutritional and medicinal values, ISHS Acta Horticulturae, vol. 809, pp. 241248, 2009.

Research Articles