International Journal of Pharmaceutical Chemistry 2018-05-22T11:05:21+00:00 Editor in Chief Open Journal Systems <p align="justify"><strong>International Journal of Pharmaceutical Chemistry (IJPC)&nbsp; </strong>publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.<br> Our mission is to advance the science and practice of pharmaceutical chemistry by working to develop and maintain competence, ethics and integrity and the highest professional standards in the specialty for the benefit of the public. The Faculty seeks, through its activities, to bring about an improvement in the health of the public.</p> Synthesis of New Barbiturate Esters derivatives as Intravenous Anesthetics: A new Dimension of Anesthesia Route: part-II* 2018-05-22T11:05:21+00:00 Md. Ehsanul Huq <p>Conventional 1-methyl-2-oxobarbiturates and 1-methyl-2-thiobarbituates which are employed as anesthetics tend to accumulate in the body due to their slow rate of metabolism. As a result, the use of these compounds is restricted to either as an induction agent for anesthesia, subsequently maintained by volatile anesthetics or to a short surgical procedures only. In order to overcome the limitations of application of barbiturates as general anesthetics, avoiding the use of volatile agents, an attempt was made to the structural modifications of barbiturates molecules as intravenous anesthetics. In view of this contexts, it was conceived that, by incorporating metabolically labile ester functions in one or both of the side chain of barbiturates ring system, it could be achieved. Since this procedure could diminish the likelihood of barbiturates to be accumulated in the body, it might be possible to get safer barbiturate intravenous anesthetics.  This classification arose from the observation that whilst the biological properties of some drugs are extremely sensitive to minor changes in stereo-chemical feature, electron distribution and substituent, there are many other drugs which exhibit similar patterns of biological behavior, despite a wide diversity in their chemical configurations. This has been appeared to be the case with the barbiturate esters as discussed in this communication.  </p> 2018-05-22T11:05:20+00:00 ##submission.copyrightStatement##