Comparison on hypoglycemic effect of Oyster (Pleurotusosteratus) and Reishi (Ganodermalucidum) mushroom in alloxan induced diabetic mice

  • Debendra Nath Roy Department of Pharmacy, Jessore University of Science and Technology, Jessore- 7408,
  • A. K. Azad Department of Pharmacy, Bangladesh University, Mohammadpur, Dhaka-1211
  • Rokshana Sharmin Department of Pharmacy, Jessore University of Science and Technology, Jessore- 7408,
  • A. S.M. Anisuzzaman Department of Pharmacy, University of Rajshahi, Rajshahi-6205
  • Proma Khondkar Department of Pharmacy, University of Rajshahi, Rajshahi-6205
Keywords: hypoglycaemic, Alloxan induced diabetic mice, blood glucose, liver cell


Pleurotusosteratus (family: Pleurotaceae) and Ganodermalucidum (family: ganodermataceae) are common edible mushrooms in Bangladesh. Ethyl acetate extract of Pleurotusosteratus and Ganodermalucidum were used to find out their hypoglycaemicactivity in alloxan induced diabetic mice. Ethyl acetate extract of Pleurotusosteratus and Ganodermalucidum reduced blood glucose level of 39.56% and 43.27% respectively at 24 hours after intrapertitoneal administration (P<0.005) inalloxan induced diabeticmice.The possible mechanism of hypoglycemic action is due to the increased glucose uptake in liver cells because it markedly lowers the blood glucose levels in alloxan induced diabeticmice.


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Pandikumar P, Babu NP, Ignacimuthu S. Hypoglycemic and antihyperglycemic effect of Begonia malabarica Lam. in normal and streptozotocin induced diabetic rats. J Ethnopharmacol.2009; 124:111115.

Iraj H, R Vida, R Sara and AAfsaneh, (2009). Chronic complications of diabetes mellitus in newly diagnosed patients. International J. diabetes Mellitus, 4: 34-37. doi:10.1016/j.ijdm.2009.08.001.

Wild et al., 2004 Global prevalence of diabetes:Estimates for the year 2000 and projections for 2030.Diabetes care,27:1047-1053.

Barak FSK. Essentials of Pharmacotherapeutics.3rd ed. S. Chand and Company Ltd.New Delhi: 2000.

Devlin.MT. Text book of Biochemistry. 4th ed. Wileylisslnc: New York:1997.

Wilke MS, French MA, Goh YK, Ryan EA, Jones PJ, ClandininMT(2009) Synthesis of specific fatty acids contributes to VLDLtriacylglycerolcomposition in humans with and without type 2diabetes. Diabetologia 52(8):16281637. doi:10.1007/s00125-009-1405-9.

Baynes, JW. and SR Thorpe, (1996). The role of oxidative stress in diabetic complications. Endocrinol., J. 3: 277-284.

K.M. Ali, K. Chatterjee, D. De, T. K. Bera and D. Ghosh, Efficacy of aqueous extract of seed of Holarrhenaantidysenterica for the management of diabetes in experimental model rat: A correlative study with antihyperlipidemic activity, International J. Applied Res. in Natural Products, 2 (3), 2009, 13.

M. Modak, P. Dixit, J. Londhe, S. Ghaskadbi and T. P. A. Devasagayam, Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes, J. Clin. Biochem.Nutr. 40 (3), 2007, 163-173.

.Grover,.JK. S. Yadav and V. Vats, (2002). Medicinal plants of India with antidiabetic potential. J. Ethanopharmacol., 81: 81-100.

Venkateshs, S., J. Thilagavathi and D. Shyam, (2007). Antidiabetic activity flowers Hibiscus rosasinesis. J. Fitoterapia, 16: 32-36.

Ghosh C. 1990. Nutritional value of edible mushroom.In thebiology and cultivation of edible mushroom. New York:Academic press.

Alam N, Amin R, Khan A, Ara I, Shim MJ, Lee MW, LeeTS. Nutritional analysis of cultivated mushrooms in Bangladesh:Pleurotusostreatus, Pleurotussajor-caju, Pleurotusflorida and Calocybeindica. Mycobiology 2008;36:228-32.

Klupp NL, Chang D, Hawke F, Kiat H, Grant SJ, Bensoussan A (2008)Ganodermalucidumfor the treatment of cardiovascular risk factors.CochraneDbSyst Rev 3. doi:10.1002/14651858.CD007259.

Wasser SP, Weis AL (1999) Therapeutic effects of substances occurring in higherbasidiomycetes mushrooms: a modernperspective. Crit Rev Immunol 19(1):6596.

Breene, W. Nutritional and medicinal value of speciality mushrooms. Journal of Food Protection, 53, 883894 (1990).

Antishigella activity of Hemigraphishirta T. Anders and AchyranthusferrugineaRoxb. A dissertation submitted to the department of Pharmacy, University of Rajshahi in partial fulfillment of the requirements for the degree of Master of Pharmacy by A.H.M.KhurshidAlam, 1999.

IDF,2007.Diabetes Atlas.3rdEdn.

O.Rahman et al-2011Socio demographic and health related determinants of over weighted diabetic patients in Bangladesh,J.Biological sciences4(3):337-344,2012.

G. Sumana and S.A. Suryawanshi, Effect of Vincarosea extracts in treatment of alloxan diabetes in male albino rat, Indian J. Exp. Biol., 39, 2001, 748-759.

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