Investigation of cerebroprotective effect of Bixa orellana on sodium nitrite induced hypoxic neurotoxicity

  • Syeda Nishat Fathima Assistant Professor, Jayamukhi College of Pharmacy
  • K. Lakshman Kumar Associate Professor, Department of Pharmacognosy, Trinity College of Pharmacy, Karimnagar, Telangana
  • K. Shailusha Department of Pharmacology, Jayamukhi College of Pharmacy, Narsampet, Warangal, Telangana
Keywords: Cerebroprotective, Hypoxia, Bixa orellana


The present study was carried out to evaluate the cerebroprotective effects of ethanolic extract of Bixa orellana leaves in hypoxic neurotoxicity induced rats. Hypoxia was induced by treatment of rats with sodium nitrite in drinking water for 30 days. Bixa orellana attenuated cognitive deficits in sodium nitrite induced rats which was studied by Morris water maze test.  The extract restored the decreased levels of dopamine and increased levels of acetylcholinesterases and glutamate to the normal levels which can be compared with standard Pyritinol. The present study reveals that the ethanolic extract of Bixa orellana leaves confers cerebroprotection against sodium nitrite induced hypoxic neurotoxicity in rats.


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