Potential Herb Drug Interactions in Antidiabetic Drugs and Herbal Drugs
Home grown items are considered as more secure and patients are frequently blend it with the oral Antidiabetic tranquilizes in the treatment diabetes. But various reports state that merging of different parts of herbs and drugs are not safe. A few combinations might be valuable and some might be not safe. So before taking any natural herbs with oral Antidiabetic drugs, patient ought to counsel restorative specialist. In this paper we are abridging the reports accessible on the cooperation of home grown solutions for a portion of the oral hypoglycemic operators and ordering the result of the blend is significant and risky. An endeavor has been made to outline the collaboration of natural solution to that of the antidiabetic drugs.
Frier BM, Fisher M. Diabetes Mellitus. In: Nicki R, Brian R, Stuart H, editors. Davidson’s Principle and Practice of Medicine, 21st edition. India: Elsevier; 2010.p.735.
Dixit S, Asiri F. Pharmacological and Non-pharmacological therapies in the Management of Diabetic Peripheral Neuropathy in Type 2 Diabetes: A Comprehensive Review. Journal of Cardiovascular Disease Research. 2014; 5(4):37-48.
Chang HY, Wallis M, Tiralongo E. Use of complementary and alternative medicine among people living with diabetes: literature review. J Adv Nurs. 2007; 58(4):307–19.
Purohit P, Mishra B. Systematic Review on Interaction Studies of Synthetic Antidiabetic Drugs and Herbal Therapies. Journal of Pharmaceutical Research. 2017; 16(2):86-94.
Miller LG, Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Archives of Internal Medicine. 1998; 158(20): 2200–2211
Philp RB, Herbal remedies: the good, the bad, and the ugly. Journal of Complementary and Integrative Medicine. 2004; 1:1–11.
Swanston-Flatt SK, Day C, Bailey CJ, Flatt PR. Evaluation of traditional plant treatments for diabetes: studies in streptozotocin diabetic mice. Acta Diabetol Lat 1989; 26(1): 51-55.
Nasri H, Rafieian-Kopaei M. Herbal medicine and diabetic kidney disease. J Nephropharmacol 2013; 2(1): 1-2.
Jamila F, Mostafa E. Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J Ethnopharmacol 2014; 154(1): 76-87.
Qi LW, Liu EH, Chu C, Peng YB, Cai HX, Li P. Anti-diabetic agents from natural products- an update from 2004 to 2009. Curr Top Med Chem. 2010; 10(4):434–57.
Samad A, Shams MS, Ullah Z, Wais M, Nazish I, Sultana Y, Aqil M. Status of herbal medicines in the treatment of diabetes: a review. Curr Diabetes Rev. 2009; 5(2):102–11.
Chang CL, Lin Y, Bartolome AP, Chen YC, Chiu SC, Yang WC. Herbal therapies for type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evid Based Complement Altern Med eCAM. 2013; 2013:378657.
Mishra R, Mohd Shuaib S, Shiravan S, Mishra PS. A review on herbal antidiabetic drugs. J App Pharma Sci. 2011; 01: 235–7.
Patel DK, Prasad SK, Kumar R, Hemalatha S. An overview on antidiabetic medicinal plants having insulin mimetic property. Asian Pac J Trop Biomed. 2012; 2(4): 320–30.
Hong SH, Heo JI, Kim JH, Kwon SO, Yeo KM, Bakowska-Barczak AM, Kolodziejczyk P, Ryu OH, Choi MK, Kang YH, et al. Antidiabetic and Beta cell-protection activities of purple corn anthocyanins. Biomol Ther (Seoul). 2013; 21(4):284–9.
Bailey CJ, Day CA. Antidiabetic drugs. British journal of cardiology. 2003; 10:128-36.
Gohil, K, J. and J.A Patel, Herb-drug interactions; A Review and study based on assessment of clinical case reports in literature. Indian. J. Pharmacol., 2007, 39(3): 129-139.
Hu, Z., X, Yang, P.C. HO, SY. Chan, P.W. Heng, E.chan, W. Duan, H.L. Koh and S. Zhou, herb-drug interactions; A Literature Review. Drugs, 2005, 65(9); 1239-1282.
Naveen P, Shankar BG, Srikanth V, Laxmaiah C, Prathapani S. A review: herb-drug interactions. Indo Am J Pharm Res. 2011; 1(12):364-72.
Gray AM, Flatt PR. Actions of the traditional anti-diabetic plant, Agrimony eupatoria (agrimony): effects on hyperglycemia, cellular glucose metabolism and insulin secretion. Br J Nutr. 1998; 80(1):109–14.
Rogers T. Herb-drug interactions. Canadian AIDS treatment information exchange (CATIE) 2004:01-06. [Last accessed on 2005 Jun 9]. Available from: http://www.catie.ca/pdf/supple- e/herb%20drug%20interactions.pdf.
Ciddi Veeresam, et al. A Insight into Herb- Drug interactions. International Journal of Pharmaceutical Sciences and Nanotechnology, 2010; 2 (4).
Fug – Berman A Herb – drug interactions. Lancet 2000: 355: 134-38.
Ernst E, Littler MH. Herbal medicine. Medical clinics of North America 2002: 86(1): 149-61.
Susan Nancy Niivitabishekam, Mohammed Assad, V Satya Prasad. Pharmacodynamic interaction of Momordica charentia with Rosiglitazone in rats. Chemico Biological interactions 2009: 177:247-253.
Sachin L Badole Subhash L Bodhankar. Concomitant administrations of Petroleum ether extract of the stem bark of Pongamia pinnata (L) Pierre with synthetic oral hypoglycaemic drugs in alloxan-induced diabetic mice. European Journal of Integrative Medicine 2009: 1: 73-79.
Adriane Fug – Berman A. Herb – drug interactions. Lancet 2000: 355: 134-38.
Aslam M, Stockley IH. Interaction between Curry ingredient (Karela) and drug Chlorpropamide. Lancet 1979: 1; 607.
Wang, Z Q. et al, The effects of St John’s wort (Hypericum Perporatum) on human Cytochrome P450 activity. Clin. Pharmacol. Ther. 2001: 70: 317-326.
Sotaniemi E A, Haapakshi E, Rautio A. Ginseng therapy in noninsulin-dependent diabetic patients. Diabetes Care 1995: 18 (10): 1373-1375.
Mary L Chavez. Herbal-Drug Interactions. Int. Chem. 2005: 9(10): 1-30.
Turner RC, Cull CA, Frighi V, Holman RR. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA. 1999; 281(21):2005–12.
Hermann LS, Lindberg G, Lindblad U, Melander A. Efficacy, effective- ness and safety of sulphonylurea–metformin combination therapy in patients with type 2 diabetes. Diabetes Obes Metab. 2002; 4(5):296–304.
Jovanovic L, Hassman DR, Gooch B, Jain R, Greco S, Khutoryan- sky N, Hale PM. Treatment of type 2 diabetes with a combination regimen of repaglinide plus pioglitazone. Diabetes Res Clin Pract. 2004; 63(2):127–34.
Del Prato S, Bianchi C, Marchetti P. Beta-cell function and anti-diabetic pharmacotherapy. Diabetes Metab Res Rev. 2007; 23(7):518–27.
Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int Immunopharmacol. 2004; 4(14): 1745–55.
Yimam M, Zhao J, Corneliusen B, Pantier M, Brownell LA, Jia Q. UP780, a chromone-enriched aloe composition improves insulin sensitivity. Metab Syndr Relat Disord. 2013; 11(4): 267–75.
Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Choke- chaijaroenporn O. Antidiabetic activity of Aloe vera L. juice II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomed Int J Phytother Phytopharmacol. 1996; 3(3):245–8.
Rheman S, Choi M, Choe K, Yoo H. Interactions between herbs and antidiabetics an overview of the mechanisms, evidence, importance and management. Arch Pharm Res. 2015; 38:1281–98.
Omobhude Fidelis Aluefua, Aminu Chika, Abubakar Amali Muhammad and Aminu Usman. Interactions between Herbs and Antidiabetic Drugs: A Systematic Review. Res. J. Pharmacol.2017; 11 (5-6): 6-17.
Xiong Y, Shen L, Liu KJ, Tso P, Xiong Y, Wang G, Woods SC, Liu M. Antiobesity and antihyperglycemic effects of ginsenoside Rb1 in rats. Diabetes. 2010; 59(10):2505–12.
Cho WC, Chung WS, Lee SK, Leung AW, Cheng CH, Yue KK. Ginsenoside Re of Panax ginseng possesses significant antioxidant and antihy- perlipidemic efficacies in streptozotocin-induced diabetic rats. Eur J Pharmacol. 2006; 550(1–3):173–9.
Lee WK, Kao ST, Liu IM, Cheng JT. Increase of insulin secretion by ginsenoside Rh2 to lower plasma glucose in Wistar rats. Clin Exp Pharmacol Physiol. 2006; 33(1–2):27–32.
Yoon SH, Han EJ, Sung JH, Chung SH. Anti-diabetic effects of compound K versus metformin versus compound K-metformin combination therapy in diabetic db/db mice. Biol Pharm Bull. 2007; 30(11): 2196–200.
Vuksan V, Sung MK, Sievenpiper JL, Stavro PM, Jenkins AL, Di Buono M, Lee KS, Leiter LA, Nam KY, Arnason JT, et al. Korean red ginseng (Panax ginseng) improves glucose and insulin regulation in well-controlled, type 2 diabetes: results of a randomized, double-blind, placebo-con- trolled study of efficacy and safety. Nutr Metab Cardiovasc Dis NMCD. 2008; 18(1):46–56.
Lotlikar MM, Rajarama Rao MR. Pharmacology of a hypoglycemic principle isolated from the fruit of Momordica charantia Linn. Ind J Pharm. 1996; 28:129–33.
Tongia A, Tongia SK, Dave M. Phytochemical determination and extraction of Momordica charantia fruit and its hypoglycemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM). Indian J Physiol Pharmacol. 2004; 48(2): 241–4.
Poonam T, Prakash GP, Kumar LV. Interaction of Momordica charantia with metformin in diabetic rats. Am J Pharm Toxicol. 2013; 8:102–6.
Vijaya K, Sunitha SP, Husssain JA, Sandhya P, Sujatha D, Gopireddy G. Synergistic antihyperglycemic, antihyperlipidemic and antioxidant effects of Momordica charantia and metformin in streptozotocin induced diabetic rats. World J Pharm Res. 2014; 3:1901–80.
Anonymous. Fruit extract effect pares (Momordica charantia) and metformin against Kadar blood glucose wistar rats induced by alloxan: comparison of treatment single and combination. Ther Sci Artic. 2014:1–4.
Basch E, Ulbricht C, Kuo G, Szapary P, Smith M. Therapeutic applications of fenugreek. Altern Med Rev. 2003; 8(1):20–7.
Naidu MM, Shyamala BN, Naik JP, Sulochanamma G, Srinivas P. Chemical composition and antioxidant activity of the husk and endosperm of fenugreek seeds. LWT Food Sci Tech. 2010; 44:451–6.
Neha S, Anand K, Sunanda P. Administration of fenugreek seed extract produces better effects in the glibenclamide-induced inhibition in hepatic lipid peroxidation: an in vitro study. Chin J Integr Med. 2015; 21:1.
Guzman-Maldonado SH, Morales-Montelongo AL, Mondragon- Jacobo C, Herrera-Hernandez G, Guevara-Lara F, Reynoso-Camacho R. Physicochemical, nutritional, and functional characterization of fruits xoconostle (Opuntia matudae) pears from Central-Mexico Region. J Food Sci. 2010; 75(6):C485–92.
Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother. 2010; 44(7–8):1334–7.
Lin LZ, He XG, Lindenmaier M, Nolan G, Yang J, Cleary M, Qiu SX, Cordell GA. Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus. J Chromatogr A. 2000; 876(1–2):87–95.
Shi Z, Gao J, Yuan Y, Zhu S, Yao M. Effect of raw Radix Rehmanniae on the pharmacokinetics of pioglitazone in rats. Pak J Pharm Sci. 2014; 27(3):537–9.
Lawson LD, Cardner CD. Composition, stability and bioavailability of garlic products being used in a clinical trial. J Agric Food Chem. 2005; 53:6254–61.
Shikha C, Tamanna N, Kumar SL. Effect of Allium Sativumon the pharmacokinetic of Metformin in rat plasma: a herb–drug interaction study. Der Pharm Chem. 2011; 3:287–91.
Poonam T, Prakash GP, Kumar LV. Effect of co-administration of Allium sativum extract and Metformin on Blood glucose of Streptozotocin induced diabetic rats. J Intercult Ethnopharmacol. 2013; 2:81–4.
Rafieian-Kopaei M, Baradaran A, Merrikhi A, Nematbakhsh M, Madihi Y, Nasri H. Efficacy of Co-administration of garlic extract and metformin for prevention of gentamicin-renal toxicity in wistar rats: a biochemical study. Int J Prev Med. 2013; 4(3): 258–64.
Tavafi M. Protection of renal tubules against gentamicin induced nephrotoxicity. J Renal Inj Prev. 2013; 2(1):5–6.
Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci. 2011; 24(4):565–70.
Anonymous. Nutrition Facts for sesame oil per 100 g, analysis of fats and fatty acids. In: National nutrient database for standard reference release 28 United States Department of Agriculture (USDA); 2014.
Sankar D, Rao MR, Sambandam G, Pugalendi KV. A pilot study of open label sesame oil in hypertensive diabetics. J Med Food. 2006; 9(3):408–12.
Sankar D, Ali A, Sambandam G, Rao R. Sesame oil exhibits synergistic effect with anti-diabetic medication in patients with type 2 diabetes mellitus. Clin Nutr. 2011; 30(3):351–8.
Carella A, Marinelli T, Melfitano A, Di Pumpo M, Conte M, Benvenuto A. Hypoglycemia by Ginseng in type 2 Diabetic Patient: case Report. Heighpubs Obes Diabetes Metab Syndr. 2017; 1:001–6.
Rhoades KR. Prescribed medications and OTCs: interactions and thiming issues. Diabetes Spectrum. 2002; 15:256–61.
Bushra R, Aslam B, Khan AY. Food–drug interactions. Oman Med J. 2011; 26:77–83.
Cho HJ, Yoon IS. Pharmacokinetic interactions of herbs with cytochrome p450 and p-glycoprotein. Evid Based Complement Altern Med eCAM. 2015:736431.
Zhou SF, Li ZW, Chen CG, Yu X, Xue Q, Herrington CC. Identification of drugs that interact with herbs in drug development. Adrian Drug Disc Today. 2015; 12:664–73.
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