A comparative trial on the efficacy of vitamin c as add on therapy to the oral hypoglycemic agent on serum lipid level in newly diagnosed type 2 diabetes mellitus
Background: Diabetic patients are more prone to develop cardiovascular diseases due to rise in blood glucose and serum cholesterol level. There will be elevated free radicals and decreased antioxidants like vitamin C level in these patients. Vitamin C has shown beneficial effect in controlling serum lipids and blood glucose level.
Aim: to study the effect of different doses of Vitamin C on serum lipid level
Methods: A total of 90 patients with newly diagnosed type 2 diabetes referred to Government Hospital, Chennai, India, were included in the study. Patients were divided into 3 groups. They received randomly glibenclamide 5mg, glibenclamide 5mg with vitamin C 1g and glibenclamide 5mg with vitamin C 2g orally for 8-weeks. Investigations like Fasting blood sugar (FBS), Postprandial blood sugar (PPBS), Lipid profile: LDL, HDL, TG, TC were measured before and after vitamin C consumption and the results were analyzed.
Results: Significant increase in HDL level (p<0.01)seen in group supplemented with vitamin C 2g when compared to group supplemented with vitamin c 1gm at the end of 8th week. There was significant reduction in TG, LDL and TC level in each group at the end of 8th week but no significant difference in between the groups.
Conclusions: Vitamin C in a dose of 2g/day as add on therapy to oral hypoglycemic agent produces improvement in lipid profile to the desirable levels and thus reducing the risk of diabetic complications.
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