Anticonvulsant activity of Granisetron in Albino mice

  • Sathisha Aithal S.S. Institute of Medical Sciences and research centre, Davangere
  • Balaji V Post graduate, Department of Pharmacology, S.S. Institute of Medical Sciences and Research Centre, Davangere.
  • Geetha S Post graduate, Department of Pharmacology, S.S. Institute of Medical Sciences and Research Centre, Davangere.
  • Swetha ES Post graduate, Department of Pharmacology, S.S. Institute of Medical Sciences and Research Centre, Davangere.
  • Udupa AL Senior Lecturer, Department of Pharmacology, Faculty of Medical Sciences, University of West Indies Medical School, Cave Hill Campus, Barbados
Keywords: IPRs, patent, design, trade mark, copy right

Abstract

The objective of this study was to investigate the anticonvulsant activity of 5-HT 3 antagonist, granisetron in albino mice. In this study granisetron (0.5mg/kg, i.p.) was administered 30 minutes prior to application of electroshock (60mA, 02.seconds) or administration of pentylenetetrazole. Granisetron significantly reduced the duration of tonic hind limb extension in maximum electroshock seizure (MES) test. In pentylenetetrazole (PTZ) test, granisetron delayed the onset and the decreased the duration of convulsions compared to control group. The percentage of animals protected in MES and PTZ models were 66 and 83 respectively. The results showed that granisetron at dose of 0.5mg possess anticonvulsant activity in both MES and PTZ models.

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Published
2015-05-30
How to Cite
1.
Aithal S, V B, S G, ES S, AL U. Anticonvulsant activity of Granisetron in Albino mice. IJPR [Internet]. 30May2015 [cited 19Apr.2019];5(5):119-21. Available from: https://ssjournals.com/index.php/ijpr/article/view/1973
Section
Research Articles