Acute Toxicity Studies and Phytochemical Screening of Aqueous and Ethyl Acetate Stem Bark Extracts of Securidaca longipedunculata Fresen (Polygalaceae)
Acute toxicity assessment of chemicals and herbal products is usually conducted to predict toxicity and provide guidelines for selecting safe doses for humans. The present study was aimed to determine the phytochemical constituents and medial lethal dose (LD50) of aqueous and ethyl acetate extracts of Securidaca longipedunculta stem bark using the basic phytochemical screening, Up and Down Procedure (UDP) and Lorke’s method. The result shows that glycosides, steroids, terpenoids, alkaloids flavonoids, saponins, anthraquinones, phenolic compounds and carbohydrates were all detected in both extracts. The medial lethal dose (LD50) of the ethyl acetate extract was greater than 5, 000 mg/kg body weight, while that of the aqueous extract was found to be above 2, 000 mg/kg body weight. It can be concluded that the aqueous and ethyl acetate stem bark extracts of Securidaca longipedunculta were slightly toxic and practically non-toxic respectively.
Copyright (c) 2018 International Journal of Pharmacological Research
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- Author must Submit Copyright form After acceptance of Article