In vivo antioxidant and anti-inflammatory effects of Balanites aegyptiaca (l) del (Balanitaceae) galls and leaves
Biologycal screening of Balanites aegyptiaca
AbstractBalanites aegyptiaca is a plant with extensive medicinal properties. The present study aims to evaluate the anti-inflammatory effect of B. aegyptiaca trough the turpentine-induced inflammation. The aqueous acetone extracts of galls and leaves have been used to test the anti-inflammatory effects on adult male Wistar-Bratislava albino rats. Total leucocyte count was performed with an optical microscope (Olympus), using a Burcker-TÃ¼rk counting-chamber. The nitric oxides synthesis (NOx), the total oxidative status (TOS) and total antioxidant response (TAR) of the serum were measured using a colorimetric assay. The results have showed that all the extracts reduced significantly (p 0.0001) the total leukocytes and total nitrites and nitrates levels in the rats serum. The oxidative stress evaluation showed that the treatment with any dose of B. aegyptiaca extracts was significantly decreased (p 0.0001) the total oxidative status. TAR increasing did correlated to TOS decrease by comparison with the inflammation group. In general, an interesting anti-inflammatory effect was found in this study with the greatest activity found in the gall extracts. B. aegyptiaca could then be a potential source of natural antioxidants and anti-inflammatories.
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