Metformin HCl, Ion-exchange resin, Controlled release
Background: The etiologic role of a pathogenic dental plaque biofilm in the development of gingivitis and dental caries is well documented. This study evaluates the rationale for incorporating sea salt based mouth rinse into a daily oral hygiene regimen along with mechanical plaque control methods on gingival inflammation and caries susceptibility level in mild to moderate gingivitis patients. Methods: A prospective, double-blinded, randomized parallel-group controlled study involving 40subjects was conducted to assess efficacy and safety. Subjects were randomized to receive either the study rinse (H2Ocean)or a water-only preparation. The oral hygiene index (OHI) and S. Mutans Level were measured at baseline and at the end of the study period. Results: Sea salt mouth rinse was significantly better than the control, with respect to both the change in OHI score by 28.89% and S. mutans level by 35%. No adverse effects were noted in any of the study groups. Conclusion: Sea Salt mouth rinse is a safe and effective treatment for preventing the development of gingival inflammation and S. mutans level in mild to moderate gingivitis population. Further research is needed to evaluate its long-term effects.
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