Background: Patients with type 2 diabetes have an increased prevalence of dyslipidemia. A timely intervention to normalize circulating lipids could reduce the chances of cardiovascular diseases. Glycated hemoglobin (HbA1c) is the indicator of glycemic status over long term. This study was conducted to find the association between HbA1c and lipid profiles in patients with type 2 diabetes mellitus. Methods: A confirmed 52 cases with type 2 diabetic mellitus were enrolled in the study. Fasting blood samples were collected and different lipid fractions along with fasting blood glucose were estimated by enzymatic method. LDL-C and VLDL-C were determined by Friedewalds formula Glycated hemoglobin (HbA1c) with radioimmunoassay. Results: HbA1c has significant positive correlation (p 0.016-0.001) with FBG, TC, TG, LDL-C and LDL-C/HDL-C. Among the lipid components, TC has significant positive correlations (p 0.007-0.001) with TG, LDL-C,TC/HDL-C,TG/HDL-C and LDL-C/HDL-C, where as TG has significant positive correlations (p 0.001) with TC/HDL-C and TG/HDL-C.HDL-C has significant negative correlations (p 0.002-0.0001) with TC/HDL-C, TG/HDL-C and LDL-C/HDL-C whereas, LDL-C has significant positive correlations (p 0.001) with TC/HDL-C and LDL-C/HDL-C. VLDL-C has significant positive correlation (p 0.001) with HDL-C and significant negative correlation (p 0.002) with TG mg/dl. Lastly, TC/HDL has significant positive correlation (p 0.001) with TG/HDL-C and LDL-C/HDL-C. Conclusion: Significant positive correlation of HbA1c with lipid profiles suggested that HbA1c can also be used as predictor of Dyslipidemia in addition to as a glycemic control parameter.
Assamang G, Schute H. The prospective Cardiovascular Minister (procam) study; Prevalence of hyperlipidemia in persons with hypertension and/or diabetes mellitus and the relationship to coronary heart disease. American Heart Journal 1988; 116:1713.
King H, Aubert RE, Herman WH. The global burden of diabetes (1995-2025), and its prevalence, numerical estimates and projections. Diabetes Care 1998; 21:1414-31.
Fall CH. The non-industrialized countries and affluence. British Medical Bulletin 2001; 60:33-50.
Bjork S, Kapur A, King H. The global policy aspects of diabetes in India. Health Policy 2003; 66:61-72.
Rao C R, Kamath V G, Shetty A, Kamath A. A study on prevalence of type 2 diabetes in coastal Karnataka. Int. J. Diabetes Dev Ctries 2010; 30(2):80-85.
Yki-Yarvinen, H.1998. Toxicity of hyperglycemia in type 2 diabetes. Diabetes Metab Rev. 14(Suppl 1): S45-S50.
Haffner SM. Lipoprotein disorders associated with type 2 diabetes mellitus and insulin resistance. Am J Cardiol. 2002; 90:55-61.
Goldberg IJ. Clinical review 124: Diabetic dyslipidemia: causes and consequences. J Clin Endocrinol Metab.2001; 86:956-971.
Ginsberg HN. REVIEW: Efficacy and mechanisms of action of statins in the treatment of diabetes dyslipidemia. J Clin Endocrinol Metab. 2006; 91:383-392.
Mooradian AD, Haas MJ, Wehmeier KR, Wong NC. Obesity related changes in high density lipoprotein metabolism. Obesity (Silver Spring). 2008; 16:1152-1160.
Mooradian AD, Haas MJ, Wong NC. Transcriptional control of apolipoprotein A-1 gene expression in diabetes. Diabetes.2004; 53:513-520.
Yokoyama H, Emoto M, Fujiwara S, Motoyama K, Morioka T, Komatsu M, Tahara H, Koyama H, Shoji T, Inaba M, Nishizawa Y. Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment are useful indexes of insulin resistance in type 2 diabetic patients with wide range of fasting plasma glucose. J Clin Endocrinol Metab 2004; 89: 1481-4.
Gligor Ramona et al. Relationship between glycosylated hemoglobin and lipid metabolism in patients with type 2 diabetes. 2011; 21(2): pp. 313-318.
Boden G; Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes, 1997; 46(1):47-55.
Mgonda YM, Ramaiya KL, Swai AB, McLarty DG, Alberti KG; Insulin resistance and hypertension in non obese Africans in Tanzania. Hypertension, 1998; 31(1):114-118.
Carmena R; High risk of lipoprotein dysfunction in type 2 diabetes mellitus. Rev Esp Cardiol Supl., 2008; 8 (supl C): 18C-24C.
Wexler, D.J., Grant, R.W., Meigs, J.B., Nathan, D.M and Cagliero, E. Sex disparities in the treatment of cardiac risk factors in patients with type 2 diabetes. Diabetes Care, 2005; 28:514-520.
Harno KE, Nikkila EA, Kuusi T; Plasma HDL cholesterol and post hepatic plasma hepatic endothelial lipase activity. Relationship to Obesity and NIDDM. Diabetologia, 2008; 19: 281-285.
Erciyas, F., Taneli, F., Arslan, B., and Uslu, Y. Glycemic control, oxidative stress and lipid profile in children with type 1 Diabetes Mellitus. Arch. Med. Res. 2004; 35:134-140.
Rohlfling, C.L., Wiedmeyer, H.M., Little, R.R., England, J.D., Tennill, A. and Goldstein, D.E. Defining the relationship between plasma glucose and HbA1c: analysis of glucose profiles and HbA1c in Diabetes Control and Com-plications trial. Diabetes Care 2002; 25: 275-278.
Khaw, K.T., Wareham, N., Luben, R., Bingham, S., Okas, S., Welch, A., Glycated hemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk). Br. Med. J. 2001; 322:15-18.
How to Cite
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
- An author must submit Copyright form After acceptance of the article.