The present paper deals with evaluation of synergistic effect of two medicinal plants, Ponamia pinnata Linn and Psoralea corylifolia Linn . Extraction was carried out with soxhlet apparatus using the solvent ethanol. The anti-psoriatic activity was done by Induction of psoriasiform changes in guinea pig by propranolol method and Rat UV B rays Photo dermatitis model for psoriasis. Antimicrobial activity by plate hole diffusion method. Ethanolic extract exhibited significant effect of anti-psoriatic and antimicrobial activity. Both the extracts show synergistic effect on both psoriasis and antimicrobial studies when compared with the individual extracts
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