Currently used steroidal and non steroidal anti-inflammatory drugs have severe side effects. These side effects are very difficult to manage than the disease itself. Hence, there is to search new safe resources to cure such diseases that the use of plant based drugs. This study deals with anti-inflammatory evaluation of the hydroalcoholic extract of Ipomoea aquatica leaves as well as their possible mechanism of action. A carrageenan‐induced rat paw oedema model was used for anti-inflammatory study. The mechanism/s by which Ipomoea aquatica is mediated the ant-inflammatory activity was determined by its effects in antihistamine activity, prostaglandin synthesis inhibition activity, membrane stabilizing activity and protein denaturation inhibition activity. Dose dependent anti-inflammatory activity was found with HAEIA in rat paw oedema model using carrageenan. HAEIA effective to suppressed the wheal area formed by histamine. HAEIA revealed dose dependent prostaglandin synthesis inhibition activity. HAEIA was effectively inhibited the heat induced hemolysis of HRBCs as well as heat induced albumin denaturation. Therefore, it was concluded that the HAEIA has anti-inflammatory activity possibly mediated through inhibition of release of mediator histamine and prostaglandin and has also HRBCs membrane stabilization and protein denaturation inhibition properties.
Di RM, Willoughby DA. Screens for anti-inflammatory drugs. J Pharm Pharmacol 1971; 23(4): 297-8.
Salvemini D, Wang ZQ, Bourdon DM, Stern MK, Currie MG, Manning PT. Evidences of peroxynitrite involvement in the carrageenan- induced rat paw edema. Eur J Pharmacol 1996a; 303: 217-20.
Bohlin L. Structure–activity studies of natural products with anti‐inflammatory effects. In Hostettmann K, editor. Phytochemistry of plants used in traditional medicine. Oxford: Clarendon Press; 1995. P. 67‐9.
Yesilada E, Ustun O, Sezik E, Takaishi Y, Ono Y, Honda G. Inhibitory effects of Turkish folk remedies on inflammatory cytokines: interleukin‐1, interleukin‐1 & tumour necrosis factor. J. Ethanopharmacol 1997; 58(1):59‐73.
Omudhome Ogbru, Nonsteroidal Antiinflammatory Drugs (NSAIDs), Inc. [cited in 2014]. Available from: http://www.medicinenet.com/nonsteroidal_antiinflammatory_drugs/article.htm.
Nadkarni KM, Indian Materia Medica. Vol. 1. Mumbai: Popular Prakashan; 1982. p.684.
Kirtikar KR & Basu BD, Indian Medicinal Plants. Vol. 3. Delhi: International Book Distributors; 1993, p.1724.
Swati J, Vipin Kumar G, Pramod Kumar S. Anti-Inflammatory Activity of Aqueous Extract of Beta Vulgaris L. Journal of Basic and Clinical Pharmacy 2011; 2(2):83-6.
Arawwawalaa LDAM, Arambewelaa LSR, Ratnasooriya WD. Alpinia calcarata Roscoe: A potent antiinflammatory agent. Journal of Ethnopharmacology 2012; 139:889–92.
Govindappa M, Naga Sravya S, Poojashri MN, Sadananda TS, Chandrappa CP. Antimicrobial, antioxidant and in vitro anti-inflammatory activity of ethanol extract and active phytochemical screening of Wedelia trilobata (L.) Hitchc. Journal of Pharmacognosy and Phytotherapy 2011; 3(3):43-51.
Ruangsang P, Tewtrakul S, Reanmongkol W. Evaluation of the analgesic and antiinflammatory activities of Curcuma mangga Val and Zijp rhizomes. Journal of Natural Medicines 2010; 64:36–41.
Cuzzocrea S, Zingarelli B, Hake P, Salzman AL, Szabo C. Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger in carrageenan-induced models of inflammation. Free Radical Biology and Medicine 1998; 24:450–9.
Ueno A, Naraba H, Ikeda Y, Ushikubi F, Murata T, Naramiya S, Ohishi S. Intrinsic prostacyclin contributes to exudation induced by bradykinin or carrageenan: a study on the paw oedema induced in IP-receptor-deficient mice. Life Sciences 2000; 66:155–60.
Tian YQ, Kou JP, Li LZ, Yu BY. Anti-inflammatory effects of aqueous extract from radix Liriope muscari and its major active fraction and component. Chin J Nat Med 2011; 9(3): 222-6.
Hossain H, Jahan AI, Nimmi I, Hossain A, Kawsar H. Antiinflammatory activity of the ethanolic extract of Acrostichum aureum (Linn.) root. Bangladesh Pharm J 2011; 14(2): 107-9.
Lindsey K, Jager AK, Raidoo DM, Staden JV. Screening of plants used by South African traditional healers in the treatment of dysmenorrhoea for prostaglandin synthesis inhibitors and uterine relaxing activity. Journal of Ethnopharmacology 1999; 64:9–14.
Chou CT. The anti inflammatory effect of Tripterygium wilfordihook on adjuvant induced paw edema in rats and inflammatory mediators release. Phytother Res 1997; 11:152-4.
Mizushima Y, Kobayashi M. Interaction of anti-inflammatory drugs with serum proteins, especially with same biologically active proteins. Journal of Pharmacy and Pharmacology 1968; 20(1):169-73.
Sakat S, Juvekar AR, Gambhire MN. In vitro antioxidant and anti-inflammatory activity of methanol extract of Oxalis corniculata Linn. Int J Pharm Pharmacol Sci 2010; 2(1):146-55.
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